炎症与子宫内膜容受性的研究进展

Research progress on inflammation and endometrial receptivity

炎症是各种病理生理过程和疾病中的关键参与者,特别是在整个妊娠周期中,炎性反应在排卵、胚胎着床、胎盘形成以及妊娠维持的各个阶段均发挥重要作用。然而,过度的炎症活动会损害子宫内膜容受性,可能导致不孕症、反复植入失败和复发性流产等临床问题,进而对女性的生殖健康和妊娠结果造成负面影响。研究显示,约有三分之二的胚胎植入失败与子宫内膜容受性不足相关。因此,炎性状态的精准调控对于提高妊娠率和改善妊娠结局具有重要意义。

Inflammation is a key player in various pathophysiological processes and diseases,especially throughout the gestational cycle,and inflammation plays an important role in ovulation,embryo implantation,placental formation,and all stages of pregnancy maintenance.However,excessive inflammatory activity can impair endometrial receptivity,which can lead to clinical problems such as infertility,recurrent implantation failure,and recurrent miscarriage,which in turn can negatively impact women's reproductive health and pregnancy outcomes.Studies have shown that about two-thirds of embryo implantation failures are associated with inadequate endometrial receptivity.Therefore,the precise regulation of inflammatory states is of great significance for increasing pregnancy rates and improving pregnancy outcomes.