c-Src在胆管癌中的表达及其临床意义

The expression and clinical significance of c-Src in cholangiocarcinoma

目的研究c-Src在胆管癌(CCA)中的表达及其与临床病理特征的关系。方法选取2017年1月至2022年12月在拉萨市人民医院行手术切除的68例CCA患者的胆管组织和18例胆总管结石患者的正常胆管组织。应用SP免疫组化法,检测胆管组织中c-Src的表达情况,分析c-Src在CCA中的表达及其与临床病理特征的关系。结果c-Src在CCA组织中的阳性表达率为58.82%(40/68),明显高于正常胆管组织的16.67%(3/18,P<0.01)。在有转移的CCA组织中c-Src的表达评分明显高于无转移的CCA组织(P<0.01)。结论c-Src在CCA组织中表达明显升高,且在有转移的CCA组织中c-Src表达明显更高,表明c-Src促进CCA的侵袭与转移。

Objective To investigate the expression of c-Src in cholangiocarcinoma(CCA)and its relationship with clinical pathological features.Methods The bile duct tissue of 68 CCA patients who underwent surgical resection at the Lhasa People's Hospital from January 2017 to December 2022 and the normal bile duct tissue of 18 patients with common bile duct stones were selected.The expression of c-Src in bile duct tissue was detected using SP immunohistochemistry,and the expression of c-Src in CCA and its relationship with clinical pathological features were analyzed.Results The positive rate of c-Src in CCA tissue was 58.82%(40/68),significantly higher than the 16.67%(3/18,P<0.01)in normal bile duct tissue.The expression score of c-Src in CCA tissues with metastasis was significantly higher than that in CCA tissues without metastasis(P<0.01).Conclusions The expression of c-Src is significantly increased in CCA tissues,and the expression of c-Src is also significantly increased in CCA tissues with metastasis,indicating that c-Src promotes the invasion and metastasis of CCA.