摘要
Yu et al.[1]reported that the tumor necrosis factor(TNF)receptor OX40(CD134)-TNF receptor-associated factor 6(TRAF6)axis mediates Lys63-linked ubiquitination and subsequent lysosomal degradation of cytotoxic T-lymphocyte antigen 4(CTLA-4),leading to the enhancement of CD8^(+)T-cell-mediated antitumor immunity.Their findings unveil a previously unknown mechanism in controlling the stability of the immune checkpoint CTLA-4 and provide a potential therapeutic target for the improvement of Tcell-based immunotherapy.
基金
funded by the Key Project of the National Natural Science Foundation of China(81830093)
the Non-Profit Central Research Institute Fund of CAMS(2022-RC310-05,2021-RC310-003,2020-RC310-002)
CAMS Initiative for Innovative Medicine(2022-I2M-2-001)
the National Natural Science Foundation of China(82372944).
