余甘子提取物及其复配物改善大鼠的功能性消化不良症状

Phyllanthus emblica L.Extract and Its Formulated Products Ameliorate Functional Dyspepsia Symptoms in Rats

该研究通过《保健食品功能检验与评价方法(2022年版)》中的促进消化功能检验方法中小鼠小肠运动、大鼠增重、摄食量、食物利用率、胃蛋白酶测定等试验研究了余甘子单方和四种复方的促消化效果。结果表明,余甘子(单方组),余甘子、山楂、茯苓和陈皮(复方1组),余甘子、山楂、白术和麦芽(复方2组),余甘子、山楂、茯苓、白术和陈皮(复方3组),余甘子、山楂、茯苓、白术、麦芽和陈皮(复方4组)小鼠小肠推进率分别提高了65.99%、80.53%、107.91%、67.47%、90.47%(P<0.05,P<0.01,P<0.0001,P<0.05,P<0.001),大鼠胃蛋白酶活性分别增强了89.24%、60.42%、103.07%、74.56%、106.84%(P<0.01,P≥0.05,P<0.01,P<0.05,P<0.01),大鼠胃蛋白酶排出量分别增强了89.30%、60.39%、103.14%、74.69%、106.98%(P<0.01,P≥0.05,P<0.01,P<0.05,P<0.01)。此外,复方4组大鼠食物利用率增加了15.35%(P<0.05),体质量增长、摄食量无显著差异(P≥0.05),其他组别的上述3项指标均无显著影响(P≥0.05)。研究表明余甘子提取物及其复配物可有效改善大鼠功能性消化不良症状。该研究为余甘子及其复配物促消化功能产品的开发和推广提供了相应的理论参考。

In this research,small intestinal motility in mice,weight gain in rats,food intake,food utilization by rats and pepsin determination were used to examine the effects of Phyllanthus emblica L.(PEL)and four formulated products according to the digestion-promoting function test methods described in Health Food Function Inspection and Evaluation Methods(2022 edition).The results showed that the small intestinal propulsion rates of the PEL(PEL alone)group,the PEL-hawthorn(H)-Poria cocos Wolf(PCW)-Tangerine Peel(TL)group(Formulated Group 1),the PEL-H-Atractylodis Macrocephalae Rhizoma(AMR)-Hordei Fructus Germinatus(HFG)group(Formulated Group 2),the PEL-H-PCW-AMRTL group(Formulated Group 3),and the PEL-H-PCW-AMR-HFG-TL group(Forumulated Group 4)increased by 65.99%,80.53%,107.91%,67.47%,and 90.47%(P<0.05,P<0.01,P<0.0001,P<0.05,P<0.001),respectively.Their pepsin activities in rats increased correspondingly by 89.24%,60.42%,103.07%,74.56%,and 106.84%(P<0.01,P≥0.05,P<0.01,P<0.05,P<0.01),and the amounts of secreted pepsin in corresponding groups of rats increased by 89.30%,60.39%,103.14%,74.69%,and 106.98%(P<0.01,P≥0.05,P<0.01,P<0.05,P<0.01),respectively.In addition,the food utilization rates in rats of the Formulated Group 4 increased by 15.35%(P<0.05).However,there were insignificant differences in weight gain and food intakes(P<0.05)as well as the above three indicators in other groups(P<0.05).The research showed that extract of Phyllanthus emblica L.and its formulated products could effectively ameliorate the symptoms of functional dyspepsia in rats.The results of this study provides a theoretical reference for the development and promotion of digestion-promoting functional products using PEL and other formulated products.