滋阴解郁调更方治疗肝郁阴虚型围绝经期失眠

Therapeutic effect of Ziyin Jieyu Tiaogeng Formula in the treatment ofperimenopausal insomnia with liver depression and yin deficiency syndrome

目的探讨滋阴解郁调更方联合艾司唑仑片治疗肝郁阴虚型围绝经期失眠的临床效果。方法选取2021年1月—2023年1月于我院诊治的肝郁阴虚型围绝经期失眠患者106例,按照随机数表法分成2组,各53例。对照组接受艾司唑仑等常规西医治疗,观察组在对照组基础上联合滋阴解郁调更方治疗4周。观察比较2组中医证候积分、PSQI评分、ISI评分、改良Kupperman量表评分改善状况,并比较2组治疗总有效率和复发状况。结果2组治疗后失眠多梦、头重如裹、胸闷心悸、痰多脘痞积分均降低(P<0.05),且观察组较对照组低(P<0.05);2组治疗后改良Kupperman量表评分均降低(P<0.05),且观察组较对照组低(P<0.05);2组治疗后QOL-BREF评分均升高(P<0.05),且观察组较对照组高(P<0.05);2组治疗后PSQI评分和ISI评分均降低(P<0.05),且观察组较对照组低(P<0.05);观察组总有效率为94.3%(50/53),高于对照组的81.1%(43/53)(P<0.05);观察组复发率(9.4%)低于对照组(24.5%)(P<0.05)。结论滋阴解郁调更方联合艾司唑仑片能够改善肝郁阴虚型围绝经期失眠围绝经症状,改善生活质量,疗效显著,且远期复发率较低。

Objective To explore the clinical effect of Ziyin Jieyu Tiaogeng Formula combined with Eszolam tablets in the treatment of perimenopausal insomnia with liver depression and yin deficiency syndrome.Methods 106 patients with perimenopausal insomnia with liver depression and yin deficiency syndrome who were treated in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2021 to January 2023 were selected and divided into the control group and the observation group according to random number table method,with 53 cases in each group.The control group received routine Western medicine treatment such as Eszolam,while the observation group was treated with the combination of Ziyin Jieyu Tiaogeng Formula on the basis of the treatment of the control group for 4 weeks.The improvement of traditional Chinese medicine syndrome scores,PSQI scores,ISI scores,and modified Kupperman scale scores between two groups was observed and compared.The total effective rate and recurrence rate between two groups were compared.Results After treatment,the scores of insomnia,excessive dreaming,heavy sensation of head,head with binding sensation,chest tightness,palpitations,phlegm accumulation,and full bloating in epigastric region in both groups decreased(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the modified Kupperman scale scores of both groups decreased(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the QOL-BREF scores of both groups increased(P<0.05),and the observation group was higher than the control group(P<0.05).After treatment,both PSQI and ISI scores decreased in both groups(P<0.05),and the observation group was lower than the control group(P<0.05).The total effective rate of the observation group(94.3%,50/53)was higher than that of the control group(81.1%,43/53)(P<0.05).The recurrence rate of the observation group(9.4%)was lower than that of the control group(24.5%)(P<0.05).Conclusion The combination of Ziyin Jieyu Tiaogeng Formula and Eszolam tablets can improve the symptoms of perimenopausal insomnia with liver depression and yin deficiency syndrome,improve the quality of life,and have significant therapeutic effects,with a lower long-term recurrence rate.