下丘脑神经干细胞调控能量平衡与肥胖的研究进展

Research progress of hypothalamic neural stem cells regulating energy balance and obesity

近年来,作为能量代谢的中枢,下丘脑在肥胖发生发展中的作用已愈发得到重视。下丘脑中存在一类控制神经发生的干细胞,称为下丘脑神经干细胞(hypothalamic neural stem cell,htNSC),其除了具有成体神经发生的作用外,还可感受机体代谢状态并作出反应,表现为改变分化方向与分泌外泌体功能、抑制炎症通路活化等,从而调节机体能量代谢平衡。通过对下丘脑及htNSC的研究,可深入了解肥胖时机体能量代谢紊乱背后的机制,并寻找针对肥胖及代谢综合征的潜在治疗靶点。

In the recent years,as the center of energy metabolism,the role of hypothalamus in the development of obsity has been increasingly emphasised.Hypothalamic neural stem cells(htNSCs)which control adult neurogenesis play a crucial role in sensing the metabolic state of the body and maintaining energy balance by altering differentiation pathways,exosome functions,and mitigating inflammatory.By studying the hypothalamus and htNSCs,we can gain a better understanding of the mechanisms behind energy metabolism disorders in obesity and identify potential therapeutic targets for obesity and metabolic syndrome.