地奥司明治疗联合康复训练对急性缺血性脑卒中患者肢体水肿、神经功能的影响

Effects of Diosmin Therapy Combined with Rehabilitation Training on Limb Edema and Neurological Function in Patients with Acute Ischemic Stroke

目的探讨地奥司明治疗联合康复训练对急性缺血性脑卒中患者肢体水肿、神经功能及血清白细胞介素-6(IL-6)的影响。方法回顾性分析60例急性缺血性脑卒中患者的临床资料,其中发病2 d内予常规药物及康复训练治疗的30例患者为对照组,在上述治疗的基础上加用地奥司明治疗的30例患者为研究组。采用美国国立卫生院卒中量表(NIHSS)评分及改良Barthel指数(MBI)量表评估神经功能,采用ELISA法检测患者血清IL-6水平。治疗14 d后,比较2组患者的神经功能、瘫痪侧肢体水肿及血清IL-6的变化情况。结果治疗前2组的NIHSS评分、MBI评分及血清IL-6水平比较,差别均无统计学意义(P>0.05);治疗后研究组的NIHSS评分和血清IL-6水平均较对照组降低(P<0.05),MBI评分较对照组升高(P<0.05),瘫痪侧肢体水肿改善率较对照组提高(P<0.05)。结论地奥司明联合康复训练治疗急性缺血性脑卒中能有效减轻瘫痪肢体水肿,改善患者的神经功能,其机制可能是通过调节炎症因子而发挥作用。

Objective It is to investigate the effects of diosmin therapy combined with rehabilitation training on limb edema,neurological function and serum interleukin-6(IL-6)in patients with acute ischemic stroke.Methods The clinical data of 60 patients with acute ischemic stroke were retrospectively analyzed,among which 30 patients who were treated with conventional drugs and rehabilitation training within 2 days of the onset of the disease were the control group,and 30 patients who were treated with diosmin on the basis of the above treatments were the study group.The national institutes of health stroke scale(NIHSS)score and modified Barthel index(MBI)scale were used to evaluate the neurological function,and serum IL-6 levels were detected by ELISA.After 14 days of treatment,the changes in neurological function,paralysis limb edema and serum IL-6 were compared between the two groups.Results There was no significant difference in NIHSS score,MBI score and serum IL-6 level between the two groups before treatment(P>0.05).Compared with the control group,the NIHSS score and serum IL-6 level were lower(P<0.05),the MBI score and the improvement rate of paralyzed limbs edema were higher in the study group after treatment(P<0.05).Conclusion Diosmin therapy combined with rehabilitation training in the treatment of acute ischemic stroke can effectively reduce the edema of paralyzed limbs and improve the neurological function of patients,and the mechanism of which may work through the regulation of inflammatory factors.