Comamonas kerstersii细菌致病性的基因组分析

Genomic Insights of Pathogenicity of Comamonas kerstersii

为了更好地管理Comamonas kerstersii(C.kerstersii)感染,通过分析C.kerstersii菌株121606基因组中的毒力因子基因(VFGs)来了解其毒力和致病性。对已经完成测序的C.kerstersii 121606基因组,通过BLAST搜索VFDB数据库来预测其VFGs。结果表明:C.kerstersii含有大量VFGs,其中一些与其在人体内的生存和生长,以及在胃肠道和肺部的致病性有关。基因组分析表明:C.kerstersii可能是一种细胞内病原体。C.kerstersii所携带的VFGs有助于解释其在文献中所报道的胃肠道感染和临床工作中所遇到的肺部感染中的毒力和致病性,这些数据也为新型抗生素和疫苗开发提供了理想的靶点,以用于治疗C.kerstersii感染。

To achieve better management of Comamonas kerstersii(C.kerstersii)infections,the aim was to understand its virulence and pathogenicity by analyzing the virulence factor genes(VFGs)in the genome of C.kerstersii 121606.The genome was sequenced previously,and the VFGs were predicted by BLAST searching through the VFDB database.The results showed that C.kerstersii contained a large number of VFGs,some of which were exemplified to correlate to the survival and growth in humans,and the pathogenicity of C.kerstersii in the gastrointestinal tract and lungs.Genomic analysis revealed that C.kerstersii might be an intracellular pathogen.The harbored VFGs were conducive to explaining its virulence and pathogenicity in gastrointestinal tract and lung infections reported in the literature or encountered in clinic.The data also provided ideal targets for novel antibiotic and vaccine development for the therapy of C.kerstersii infections.