摘要
缺血性脑卒中(ischemic stroke,IS)是脑卒中最常见的类型,致残率、致死率高,威胁人类健康。当前,血清标志物在缺血性脑卒中的应用,包括诊断和预后方面的研究,取得了一些进展。白细胞介素、NADPH氧化酶4、脂蛋白相关磷脂酶A2、可溶性细胞间黏附分子-1、基质金属蛋白酶等指标具有较好的诊断价值。随着基因组学、转录组学和蛋白组学等领域的迅速发展,非编码RNA的发现等为IS的病理生理学机制开辟了新的方向,有望成为IS诊断、治疗及预后相关的新型血清标志物。
Ischemic stroke is the most common type of stroke,with high disability and fatality rates,threatening human health.Currently,the application of serum markers in ischemic stroke,including diagnosis and prognosis,has achieved some progresses.Interleukins,nicotinamide adenine dinucleotide phosphate oxidase,lipoprotein-associated phospholipase A2,soluble intercellular adhesion molecule,platelet activating factor,matrix metalloproteinase and other indicators have showed promising diagnostic values.With the rapid development of genomics,transcriptomics and proteomics research,the discovery of non-coding RNA has opened up novel directions for the pathophysiological mechanisms of ischemic stroke.NcRNA might serve as an important serum markers for the diagnosis,treatment and prognosis of ischemic stroke.
作者
张钟丹
李云
张冬青
ZHANG Zhongdan;LI Yun;ZHANG Dongqing(Department of Clinical Laboratory,the Fourth Medical Center of PLA General Hospital,Beijing 100048,China;Health Service Department of the Guard Bureau of the General Office of the Central Committeeof the Communist Party of China,Beijing 100032,China)
出处
《标记免疫分析与临床》
CAS
2024年第4期763-768,772,共7页
Labeled Immunoassays and Clinical Medicine
