甲亢突眼患者突眼程度与脑钠肽关系研究

Study on the relationship between the degree of exophthalmosis and brain natriuretic peptide in patients with hyperthyroidism

目的:探究甲状腺功能亢进症(甲亢)突眼患者突眼程度与脑钠肽关系。方法:选取医院收治的60例甲亢突眼患者作为研究对象。按突眼度分别为轻度突眼(19~20 mm)组、中度突眼(21~23 mm)组、重度突眼(>23 mm)组,每组20例患者,比较3组血清脑钠肽、甲状腺激素,分析甲亢突眼影响因素。结果:中度突眼组和重度突眼组患者脑钠肽水平高于轻度突眼组,重度突眼组高于中度突眼组,差异均有统计学意义(P<0.05)。中度突眼组和重度突眼组患者游离三碘甲状腺原氨酸(FT3)和血清游离甲状腺素(FT4)水平高于轻度突眼组,重度突眼组高于中度突眼组,差异均有统计学意义(P<0.05)。经有序Logistic回归分析显示,脑钠肽水平升高是甲亢突眼患者独立危险因素(P<0.05)。结论:甲亢突眼患者突眼程度越严重则脑钠肽与甲状腺激素水平越高,因此监测脑钠肽水平有利于防治甲亢突眼。

Objective:To investigate the relationship between the degree of exophthalmos and brain natriuretic peptide in patients with hyperthyroidism(hyperthyroidism).Methods:A total of 60 patients with hyperthyroidism and exophthalmoism admitted to hospital were enrolled as the study subjects.According to the degree of hyperthyroidism,the degree of hyperthyroidism was divided into mild exophthalmos(19~20 mm)group,moderate exophthalmos(21~23 mm)group,and severe exophthalmos(>23 mm)group,with 20 cases in each group,and serum brain natriuretic peptide and thyroid hormone were compared in the three groups,and the influencing factors of hyperthyroidism were analyzed.Results:The levels of natriuretic peptide in the moderate and severe exophthalmos groups were higher than those in the mild exophthalmos group,and the levels of brain natriureate peptide in the severe exophthalmos group were higher than those in the moderate exophthalmos group,and the three groups were statistically significant(P<0.05).The levels of free triiodothyronine(FT3)and serum free thyroxine(FT4)in the moderate and severe exophthalmos groups were higher than those in the mild exophthalmos group,and the levels of severe exophthalmos were higher than those in the moderate exophthalmos group,and the three groups were statistically significant(P<0.05).Ordinal logistic regression analysis showed that elevated natriuretic peptide level was an independent risk factor for patients with hyperthyroidism(P<0.05).Conclusion:The more severe the exophthalmos,the higher the levels of natriuretic peptide and thyroid hormone in patients with hyperthyroidism,so monitoring the level of natriuretic peptide is beneficial to the prevention and treatment of hyperthyroidism.