肝爽颗粒对慢性乙型病毒性肝炎患者免疫功能及肝功能的影响

The effect of Ganshuang granules on immune function and liver function in patients with chronic hepatitis B

目的:探讨肝爽颗粒对慢性乙型病毒性肝炎(CHB)患者免疫功能及肝功能的影响。方法:择取医院接诊的80例CHB患者,用随机数表法分成对照组与治疗组,各40例患者。对照组患者予西医常规治疗,治疗组患者在此基础上予肝爽颗粒治疗,持续6个月后对比两组疗效、肝功能、炎性反应及免疫功能。结果:治疗组患者总有效率高于对照组(P<0.05);治疗后,两组患者天冬氨酸氨基转移酶(AST)、γ-谷酰氨转肽酶(GGT)与丙氨酸氨基转移酶(ALT)均降低,且治疗组患者AST、GGT、ALT值更低(P<0.05);两组患者白介素-6(IL-6)、转化生长因子-β(TGF-β)与肿瘤坏死因子-α(TNF-α)均降低,且治疗组患者TGF-β、TNF-α、IL-6值更低(P<0.05);两组患者CD8+值均降低,CD4+、CD3+值均增高,且治疗组患者CD8+、CD4+、CD3+改善更优(P<0.05)。结论:肝爽颗粒治疗CHB疗效确切,可减轻患者炎性反应,提高免疫力,改善肝功能。

Objective:To explore the effects of Ganshuang granules on immune function and liver function in patients with chronic hepatitis B(CHB).Method:Eighty CHB patients admitted to hospital were randomly divided into two groups,a control group and a treatment group,with 40 patients in each group.The control group was treated with Entecavir,while the treatment group was treated with Ganshuang Granules on this basis.The efficacy,liver function,inflammatory response,and immune function of the two groups were compared for 6 months.The total effective rate of the treatment group was higher than that of the control group(P<0.05);After treatment,two groups of aspartate aminotransferase(AST)γ-Both glutamyltransferase(GGT)and alanine aminotransferase(ALT)were reduced,and the AST,GGT,and ALT levels were lower in the treatment group(P<0.05);After treatment,two groups of interleukin-6(IL-6)and transforming growth factor-β(TGF-β)Tumor necrosis factor-α(TNF-α)All decreased,and TGF in the treatment group-β、TNF-α、IL-6 is lower(P<0.05);After treatment,CD8+decreased in both groups,while CD4+and CD3+increased.The treatment group showed better improvement in CD8+,CD4+,and CD3+(P<0.05).Conclusion:Ganshuang granules have a definite therapeutic effect on CHB,which can alleviate inflammatory reactions,improve immunity,and improve liver function in patients.