加味黄芩汤联合化疗治疗湿热郁毒型结直肠癌临床观察

Efficacy observation of Huangqin decoction and chemotherapy on colorectal cancer with syndrome of toxin generated by accumulation of damp-heat

目的:观察加味黄芩汤联合化疗治疗湿热郁毒型结直肠癌的临床疗效。方法:选取符合纳入标准的结直肠癌患者60例,按照随机数字表法分为两组各30例,对照组予mFOLFOX6方案化疗,治疗组在对照组基础上予加味黄芩汤治疗。比较两组肿瘤标志物CEA及CA199水平、免疫功能、湿热郁毒证候积分、KPS评分、安全性评价等变化。结果:治疗后治疗组CD3+、CD4+、CD4+/CD8+水平及KPS评分均高于对照组(P﹤0.05);治疗组CEA及CA199水平、CD8+水平、湿热郁毒证候积分、毒副反应发生率均低于对照组(P﹤0.05)。结论:加味黄芩汤联合化疗治疗湿热郁毒型结直肠癌效果较好,能辅助化疗增加临床抗结直肠癌的疗效,改善临床症状、增强机体免疫功能。

Objective:To observe the clinical efficacy of modified Huangqin decoction and chemotherapy on colorectal cancer with syndrome of toxin generated by accumulation of damp-heat.Methods:60 cases of eligible patients with colorectal cancer were selected and randomly divided into two groups,30 cases in each group.The control group was treated by chemotherapy of mFOLFOX6 regimen,while the treatment group was treated plus with modified Huangqin decoction on the basis of control group.Levels of CEA and CA199 of tumor marker,immune function,score of syndrome of toxin generated by accumulation of damp-heat,KPS score and safety evaluation,etc.were compared between two groups.Results:After treatment,CD3+,CD4+,CD4+/CD8+and KPS score of treatment group were higher than those of control group(P<0.05).The levels of CEA,CA199 and CD8+,the score of syndrome of toxin generated by accumulation of damp-heat and the incidence rat of toxic and side reactions in the treatment group were lower than those in the control group(P<0.05).Conclusion:The clinical efficacy of modified Huangqin decoction and chemotherapy on colorectal cancer with syndrome of toxin generated by accumulation of damp-heat is better,which can assist the chemotherapy,so as to increase the clinical efficacy of anti-colorectal cancer,improve the clinical symptoms and enhance the immune function of the body.