肠杆菌科细菌感染的耐药性分析及其分布特点研究

Drug Resistance Analysis and Distribution Characteristics of Enterobacteriaceae

目的:探讨肠杆菌科细菌感染的耐药性及其临床分布特点,为临床诊治肠杆菌科细菌感染提供参考。方法:选择2019年1月—2023年6月苏州市吴中区第二人民医院临床分离的肠杆菌科细菌800株作为研究对象。对800株肠杆菌科细菌予以全自动微生物分析仪鉴定菌株情况,并实施药敏试验,总结肠杆菌科细菌临床分布特点,分析其药敏性。结果:经菌株鉴定发现,800份菌株中,肺炎克雷伯菌占比最多(300株),大肠埃希菌次之(220株),之后为肠杆菌属(包括阴沟肠杆菌与产气肠杆菌,共120株)。相关科室分离出的肠杆菌科细菌中,来自综合内科的最多,共140株。药敏试验结果显示,肺炎克雷伯菌主要对氨苄西林耐药,大肠埃希菌主要对氨苄西林、复方新诺明、环丙沙星、哌拉西林、四环素耐药,肠杆菌则主要对氨苄西林、阿莫西林/克拉维酸耐药。结论:肠杆菌科细菌感染中肺炎克雷伯菌、大肠埃希菌、阴沟肠杆菌、产气肠杆菌比较常见,以肺炎克雷伯菌、大肠埃希菌占比较高,临床需做好这些菌种的耐药性分析,为临床治疗提供参考,从而提高临床抗肠杆菌科细菌感染的治疗效果。

Objective:To explore the drug resistance and clinical distribution characteristics of enterobacteriaceae bacterial infection,and provide reference for clinical diagnosis and treatment of enterobacteriaceae bacterial infection.Methods:Eight hundred strains of enterobacteriaceae bacteria clinically isolated from Suzhou Wuzhong District Second People's Hospital from January 2019 to June 2023 were selected as the research objects.Eight hundred strains of enterobacteriaceae were identified by automatic microbiological analyzer and drug susceptibility test was carried out.The clinical distribution characteristics of enterobacteriaceae bacteria were summarized and their drug susceptibility was analyzed.Results:According to strain identification,Klebsiella pneumoniae accounted for the largest proportion(300 strains),Escherichia coli(220 strains),followed by Enterobacteria(including Enterobacter cloacae and Enterobacter aerogenes,120 strains in total).According to the enterobacteriaceae bacteria isolated from relevant departments,the general medical department has the most,140 strains.The results of drug susceptibility test showed that Klebsiella pneumoniae was mainly resistant to ampicillin,Escherichia coli was mainly resistant to ampicillin,cotrimoxazole,ciprofloxacin,piperacillin and tetracycline,and enterobacter was mainly resistant to ampicillin,amoxicillin/clavulanate.Conclusion:Klebsiella pneumoniae,Escherichia coli,Enterobacter cloacae and Enterobacter aerogenes are common in enterobacteriaceae bacterial infections,and Klebsiella pneumoniae and Escherichia coli account for a relatively high proportion.Clinical drug resistance analysis of these strains should be done to provide reference for clinical treatment,so as to improve the therapeutic effect of anti-enterobacteriaceae bacterial infections.