基于支气管肺泡灌洗液细菌核酸检测的桂林地区迁延性细菌性支气管炎病原研究

Study on the Etiology of Migratory Bacterial Bronchitis in Guilin Based on Bacterial Nucleic Acid Detection in Bronchoalveolar Lavage Fluid

目的:通过支气管肺泡灌洗液(BALF)细菌核酸检测,研究桂林地区迁延性细菌性支气管炎(PBB)患儿的病原体。方法:选取2021年7月—2023年2月桂林医学院第二附属医院儿科收治的行支气管镜检查的PBB患儿40例作为研究对象,通过支气管镜取BALF进行核酸检测,查找病原体。结果:BALF细菌核酸检测结果显示,40例PBB患儿中有38例检出病原体,病原体共检测出61株。其中,以肺炎链球菌占比最高(44.2%),流感嗜血杆菌(22.9%)次之。1~3岁年龄段病原体检出率最高,4~6岁检出率次之。结论:桂林地区PBB常见的病原体为肺炎链球菌,与社区获得性肺炎相符,可为本地区提供参考。

Objective:To study the pathogens of children with migratory bacterial bronchiolitis(PBB)in Guilin by bacterial nucleic acid detection in bronchoalveolar lavage fluid(BALF).Methods:Forty cases of children with PBB admitted to the Department of Pediatrics of the Second Affiliated Hospital of Guilin Medical College who underwent bronchoscopy from July 2021 to February 2023 were selected as the study subjects,and BALF was taken for nucleic acid testing through bronchoscopy to find the pathogens.Results:The results of BALF bacterial nucleic acid test showed that pathogens were detected in thirty-eight out of forty children with PBB,and a total of sixty-one strains of pathogens were detected;among them,Streptococcus pneumoniae accounted for the highest percentage(44.2%),followed by Haemophilus influenzae(22.9%);the detection rate of pathogens was the highest in the age group of 1-3 years old,followed by the detection rate in the age group of 4-6 years old.Conclusion:The common pathogen of PBB in Guilin is Streptococcus pneumoniae,which is consistent with community-acquired pneumonia and can provide a reference for the region.