摘要
肝细胞癌(hepatic carcinoma, HCC)是一种具有高度侵袭性和不良预后的恶性肿瘤。肿瘤微环境(tumor microenvironment, TME)是一个复杂的网络,通过大量的信号机制和途径以动态方式与肿瘤细胞相互作用,肿瘤相关成纤维细胞(cancer-associated fibroblasts, CAFs)是TME中最主要的成分,通过血管生成、纤维化、细胞增殖、免疫抑制等多个方面直接或者间接在HCC中发挥促癌或者抑癌作用。现结合文献对CAFs与原发性肝癌的研究进展进行综述。
Hepatocellular carcinoma(HCC)is a highly aggressive malignancy with a poor prognosis.tumor microenvironment(TME)is a complex network that dynamically interacts with tumor cells through a large number of signaling mechanisms and pathways.Cancer-associated fibroblasts(CAFs)are the most important components of TME.They directly or indirectly play a role in promoting or suppressing cancer in HCC through angiogenesis,fibrosis,cell proliferation,immunosuppression and other aspects.This article reviews the research progress of CAFs and primary liver cancer.
作者
薛懿
赵永忠
崔银贤
张敏
杨晓军
XUE Yi;ZHAO Yongzhong;CUI Yinxian;ZHANG Min;YANG Xiaojun(The First Clinical College of Medicine,Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;Department of General Surgery,Gansu Provincial People's Hospital,Gansu Lanzhou 730000,China;Gansu Province Prevention and Control Engineering Research Center of Digestive Tract Malignant Tumor,Gansu Lanzhou 730000,China;Key Laboratory of Diagnosis and Treatment of Gastrointestinal Tumors,National Health Commission,Gansu Lanzhou 730000,China;The First Clinical Medical College of Lanzhou University,Gansu Lanzhou 730000,China)
出处
《现代肿瘤医学》
CAS
2024年第10期1949-1953,共5页
Journal of Modern Oncology
基金
甘肃省卫生健康行业科研计划(编号:GSWSKY2020-45)
国家卫健委胃肠肿瘤诊治重点实验室2022年度硕博士/博士后基金项目(编号:NHCDP2022001)
甘肃省人民医院博士研究生导师培育项目(编号:22GSSYA-3)
甘肃省基础研究创新群体项目(编号:22JR5RA709)。
关键词
肿瘤相关成纤维细胞
肝细胞癌
肿瘤微环境
cancer-associated fibroblasts
hepatocellular carcinoma
tumor microenvironment
