美罗培南治疗老年重症肺炎的有效性和安全性分析

Efficacy and Safety Analysis of Meropenem in the Treatment of Severe Pneumonia in Elderly People

目的研究老年重症肺炎治疗过程中应用美罗培南治疗的疗效以及安全性。方法随机选取2021年4月-2022年4月济南市中西医结合医院收治的80例老年重症肺炎患者为研究对象,以随机数表法分为研究组、参照组,各40例。参照组给予血必净联合无创机械通气治疗,研究组在参照组治疗基础上给予美罗培南治疗,比较两组临床疗效、肺功能指标、不良反应总发生率、血清C反应蛋白(C-reactive Protein,CRP)、降钙素原(Procalcitonin,PCT)水平以及标准吞咽功能评定量表(Standardized Swallowing Assessment,SSA)评分。结果研究组治疗总有效率(92.50%)高于参照组(70.00%),差异有统计学意义(χ^(2)=6.646,P=0.010)。治疗前两组肺功能指标比较,差异无统计学意义(P>0.05);治疗后,研究组肺功能指标优于参照组,差异有统计学意义(P<0.05)。研究组不良反应总发生率为10.00%,低于参照组的37.50%,差异有统计学意义(P<0.05)。治疗前,两组血清CRP、PCT水平及SSA评分比较,差异无统计学意义(P均>0.05);治疗后,研究组血清CRP、PCT水平以SSA评分均低于参照组,差异有统计学意义(P均<0.05)。结论针对老年重症肺炎患者应用美罗培南治疗,可改善患者的临床症状,恢复肺功能,不良反应较少,降低血清CRP和PCT水平,吞咽能力改善显著。

Objective To study the effectiveness and safety of meropenem in the treatment of severe pneumonia in the elderly.Methods 80 elderly patients with severe pneumonia admitted to Jinan Combined Hospital of Traditional Chi-nese and Western Medicine from April 2021 to April 2022 were selected randomly as the study subjects.They were divided into a study group and a reference group using random number table method,with 40 cases in each group.The reference group was treated with Xuebijing combined with non-invasive mechanical ventilation,while the study group was treated with meropenem on the basis of the reference group.The clinical efficacy,lung function indexes,total inci-dence of adverse reactions,the leves of serum C-reactive Protein(CRP)and Procalcitonin(PCT),as well as the score of Standardized Swallowing Assessment(SSA)were compared between the two groups.Results The total effective rate of treatment in the study group(92.50%)was higher than that in the control group(70.00%),and the difference was statistically significant(χ^(2)=6.646,P=0.010).There was no statistically significant difference in lung function indexes between the two groups before treatment(P>0.05).After treatment,the lung function index in the study group was bet-ter than that in the control group,and the difference was statistically significant(P<0.05).The total incidence of ad-verse reactions in the study group was 10.00%,lower than the reference group's 37.50%,and the difference was statis-tically significant(P<0.05).There were no statistically significant differences in levels of serum CRP and PCT,and SSA scores between the two groups before treatment(all P>0.05).After treatment,the serum CRP and PCT levels,and SSA scores in the study group were lower than those in the control group,and the differences were statistically signifi-cant(all P<0.05).Conclusion Elderly patients with severe pneumonia carry out meropenem treatment,can improve the clinical symptoms of the patients,recovery pulmonary function,and have fewer adverse reactions,reduce serum CRP and PCT level,and swallowing ability improvement is significant.