支气管肺炎患者给予盐酸氨溴索静脉滴入联合口服阿奇霉素的治疗效果

Therapeutic Effect of Ambroxol Hydrochloride Intravenous Infusion Com⁃bined with Oral Azithromycin in Patients with Bronchial Pneumonia

目的分析口服阿奇霉素+静脉滴注盐酸氨溴索对支气管肺炎的治疗效果。方法方便选取2020年7月-2023年7月福建省泉州台商投资区医院儿科收治的150例支气管肺炎的患儿为研究对象,以随机数表法分为对照组与研究组,每组75例。对照组选择口服阿奇霉素治疗,研究组选择静脉滴注盐酸氨溴索+口服阿奇霉素治疗,对比两组治疗前后的症状消失时间、不良反应发生率以及炎性因子水平和动脉血气变化。结果研究组咳嗽、发热、肺部啰音、呼吸困难等症状的消失时间分别为(3.03±0.85)、(2.82±0.65)、(2.12±0.56)、(2.05±0.44)d,短于对照组的(5.41±1.16)、(5.23±1.02)、(4.63±1.35)、(4.16±1.12)d,差异有统计学意义(t=14.332、17.256、14.873、15.185,P均<0.001)。研究组不良反应发生率(9.33%),与对照组(6.67%)比较,差异无统计学意义(χ^(2)=0.362,P=0.547)。治疗前,两组血氧饱和度、肿瘤坏死因子-α、pH值、白介素-6、二氧化碳分压、C-反应蛋白、氧分压的比较,差异无统计学意义(P均>0.05)。治疗后,研究组肿瘤坏死因子-α、白介素-6、C-反应蛋白、二氧化碳分压均低于对照组,而另外3项动脉血气指标均高于对照组,差异有统计学意义(P均<0.05)。结论口服阿奇霉素+静脉滴注盐酸氨溴索治疗支气管肺炎,不仅可以改善患儿临床症状和动脉血气状况,还能减轻其炎症反应,安全性高。

Objective To analyze the therapeutic effect of oral azithromycin and intravenous infusion of ambroxol hy-drochloride on bronchial pneumonia.Methods A total of 150 children treated with bronchopneumonia in the pediat-rics department of Taiwan Investment Area Hospital in Quanzhou,Fujian Province from July 2020 to July 2023 were conveniently selected as the study objects,and they were divided into control group and study group by random num-ber method,with 75 cases in each group.The control group was given oral azithromycin,and the study group was given intravenous infusion of ambroxol hydrochloride+oral azithromycin.The duration of symptom resolution,inci-dence of adverse reactions,levels of inflammatory factors and changes in arterial blood gas before and after treatment were compared between the two groups.Results The duration of cough,fever,lung rales,dyspnea and other symptoms were(3.03±0.85),(2.82±0.65),(2.12±0.56),(2.05±0.44)d,respectively.which shorter than that of control group(5.41±1.16)d,(5.23±1.02),(4.63±1.35),(4.16±1.12)d,and the differences were statistically significant(t=14.332,17.256,14.873,15.185,all P<0.001).There was no significant difference in the incidence of adverse reactions between the study group(9.33%)and the control group(6.67%)(χ^(2)=0.362,P=0.547).Before treatment,there was no significant dif-ference in blood oxygen saturation,tumor necrosis factor-α,pH value,interleukin-6,partial pressure of carbon diox-ide,C-reactive protein and partial pressure of oxygen between the two groups(all P>0.05).After treatment,tumor ne-crosis factor-α,interleukin-6,C-reactive protein and partial pressure of carbon dioxide in the study group were lower than those in the control group,while the other three arterial blood gas indexes were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Oral azithromycin+intravenous infu-sion of ambroxol hydrochloride in the treatment of bronchial pneumonia can not only improve the clinical symptoms and arterial blood gas status of children,but also reduce the inflammatory response,and the safety is very high.