阿加曲班在体外膜肺氧合中的应用

Application of Agatroban in Extracorporeal Membrane Oxygenation

在体外膜肺氧合(Extracorporeal Membrane Oxygenation,ECMO)支持过程中,为了有效预防凝血并发症,选择合适的抗凝药物显得尤为关键。阿加曲班作为一种直接凝血酶抑制剂(Direct Thrombin Inhibitor,DTI),以其可控的抗凝监测、出色的抗凝效果和良好的安全性等特点,可能相较于传统的肝素(Unfraction-ated heparin,UFH)更为优越。本文综述了阿加曲班在ECMO中的应用,为抗凝治疗提供了更为个体化的选择,进一步丰富了ECMO抗凝策略。

In the process of extracorporeal membrane oxygenation(ECMO)support,in order to effectively prevent co-agulation complications,it is particularly important to select appropriate anticoagulant drugs.Agatroban,as a direct thrombin inhibitor(DTI),may be superior to unfractionated heparin(UFH)because of its controllable anticoagulant monitoring,excellent anticoagulant effect and good safety.This article reviewed the application of agatroban in ECMO,which provided a more individualized choice for anticoagulant therapy and further enriched the anticoagulant strategy of ECMO.