普萘洛尔联合甲巯咪唑治疗甲状腺功能亢进症患者的效果

Effects of Propranolol combined with Methimazole in treatment of patients with hyperthyroidism

目的:观察普萘洛尔联合甲巯咪唑治疗甲状腺功能亢进症患者的效果。方法:回顾性分析2020年1月至2023年9月该院收治的70例甲状腺功能亢进症患者的临床资料,根据治疗方法不同将其分为对照组和观察组各35例。对照组采用甲巯咪唑治疗,观察组在对照组基础上联合普萘洛尔治疗,比较两组治疗前后甲状腺激素指标[游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)]水平、心率、肾上腺皮质激素指标[皮质醇(Cor)、促肾上腺皮质激素(ACTH)]水平和治疗期间不良反应发生率。结果:治疗3个月时,观察组FT_(3)、FT_(4)水平均低于对照组,TSH水平高于对照组,差异有统计学意义(P<0.05);治疗3个月时,两组心率均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗3个月时,观察组血清Cor水平高于对照组,ACTH水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:普萘洛尔联合甲巯咪唑治疗甲状腺功能亢进症患者可改善甲状腺激素指标水平和肾上腺皮质激素指标水平,降低心率,效果优于单纯甲巯咪唑治疗。

Objective:To observe effects of Propranolol combined with Methimazole in treatment of patients with hyperthyroidism.Methods:The clinical data of 70 patients with hyperthyroidism admitted to this hospital from January 2020 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,35 cases in each group.The control group was treated with Methimazole,while the observation group was treated with Propranolol on the basis of that of the control group.The levels of thyroid hormone indexes[free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)],heart rate,and adrenocortical hormone indexes[cortisol(Cor),adrenocorticotropic hormone(ACTH)]before and after the treatment,and the incidence of adverse reactions during the treatment were compared between the two groups.Results:After 3 months of treatment,the levels of FT_(3) and FT_(4) in the observation group were lower than those in the control group,the TSH level was higher than that in the control group,and the differences were statistically significant(P<0.05).At 3 months of treatment,the heart rate levels of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).At 3 months of treatment,the serum Cor level in the observation group was higher than that in the control group,the ACTH level was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Propranolol combined with Methimazole in the treatment of the patients with hyperthyroidism can improve the levels of thyroid hormone indexes and adrenal cortical hormone indexes,and reduce the heart rate.Moreover,it is superior to single Methimazole treatment.