布拉酵母菌联合乳果糖治疗功能性便秘患儿的效果

Effects of Saccharomyces boulardii combined with Lactulose in treatment of children with functional constipation

目的:观察布拉酵母菌联合乳果糖治疗功能性便秘患儿的效果。方法:选取2021年1月至2023年9月该院收治的181例功能性便秘患儿进行前瞻性研究,按照随机数字表法将其分为研究组91例和对照组90例。对照组采用乳果糖口服溶液治疗,研究组在对照组基础上联合布拉酵母菌治疗,比较两组临床疗效,治疗前后胃肠激素指标[促胃液素(GAS)、促胃动素(MTL)、生长抑素(SS)]水平,临床症状改善时间,肠神经递质指标[P物质、一氧化氮(NO)]水平,以及不良反应发生率。结果:研究组治疗总有效率为94.51%(86/91),高于对照组的84.44%(76/90),差异有统计学意义(P<0.05);治疗后,两组GAS、MTL水平均高于治疗前,且研究组高于对照组,两组SS水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组排便次数正常时间和排便性状正常时间均短于对照组,差异有统计学意义(P<0.05);两组P物质水平均高于治疗前,且研究组高于对照组,两组NO水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:布拉酵母菌联合乳果糖治疗功能性便秘患儿可提高治疗总有效率,改善胃肠激素指标和肠神经递质指标水平,缩短临床症状改善时间,其效果优于单纯乳果糖口服溶液治疗。

Objective:To observe effects of Saccharomyces boulardii combined with Lactulose in treatment of children with functional constipation.Methods:A prospective study was conducted on 181 children with functional constipation admitted to this hospital from January 2021 to September 2023.According to the random number table method,they were divided into study group(91 cases)and control group(90 cases).The control group was treated with Lactulose oral solution,and the study group was treated with Saccharomyces boulardii on the basis of that of the control group.The clinical efficacy,the levels of gastrointestinal hormone indexes[gastrin(GAS),motilin(MTL),somatostatin(SS)]before and after the treatment,the improvement time of clinical symptoms,the levels of intestinal neurotransmitter indexes[substance P,nitric oxide(NO)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.51%(86/91),which was higher than 84.44%(76/90)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of GAS and MTL in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the SS levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The normal time of defecation frequency and the normal time of defecation traits in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The levels of substance P in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of NO in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Saccharomyces boulardii combined with Lactulose in the treatment of the children with functional constipation can improve the total effective rate of treatment,improve the levels of gastrointestinal hormone indexes and intestinal neurotransmitter indexes,and shorten the improvement time of clinical symptoms.Moreover,it is superior to single Lactulose oral solution treatment.