银杏叶提取物注射液联合盐酸倍他司汀治疗脑动脉供血不足性眩晕患者的效果

Effects of extract of ginkgo biloba leaves injection combined with Betahistine hydrochloride in treatment of patients with cerebral artery insufficiency vertigo

目的:观察银杏叶提取物注射液联合盐酸倍他司汀治疗脑动脉供血不足性眩晕患者的效果。方法:选取2021年6月至2022年12月该院收治的68例脑动脉供血不足性眩晕患者进行前瞻性研究,按随机数字表法将其分为对照组和研究组各34例。对照组采用注射用盐酸倍他司汀治疗,观察组在对照组基础上联合银杏叶提取物注射液治疗。比较两组临床疗效,治疗前后眩晕程度[眩晕残障程度评定量表(DHI)]评分、血流动力学指标[左侧椎动脉(LVA)、右侧椎动脉(RVA)、基底动脉(BA)血流速度]水平,以及不良反应发生率。结果:研究组治疗总有效率为88.24%(30/34),高于对照组的55.88%(19/34),差异有统计学意义(P<0.05);治疗后,两组躯体、情绪、功能等DHI评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组LVA、RVA、BA血流速度均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合盐酸倍他司汀治疗脑动脉供血不足性眩晕患者可提高治疗总有效率和血流动力学指标水平,降低DHI评分,其效果优于单纯盐酸倍他司汀治疗。

Objective:To observe effects of extract of ginkgo biloba leaves injection combined with Betahistine hydrochloride in treatment of patients with cerebral artery insufficiency vertigo.Methods:A prospective study was conducted on 68 patients with cerebral artery insufficiency vertigo admitted to the hospital from June 2021 to December 2022.According to the random number table method,they were divided into control group and study group,34 cases in each group.The control group was treated with Betahistine hydrochloride for injection,while the observation group was treated with extract of ginkgo biloba leaves injection on the basis of that of the control group.The clinical efficacy,the vertigo degree[dizziness handicap inventory(DHI)]score,the hemodynamic indexes[left vertebral artery(LVA),right vertebral artery(RVA),basilar artery(BA)blood flow velocity]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 88.24%(30/34),which was higher than 55.88%(19/34)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the DHI scores of body,emotion and function in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The blood flow velocities of LVA,RVA and BA in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Extract of ginkgo biloba leaves injection combined with Betahistine hydrochloride in the treatment of the patients with cerebral artery insufficiency vertigo can improve the total effective rate of treatment and the levels of hemodynamic indexes,and reduce the DHI scores.Moreover,it is superior to single Betahistine hydrochloride treatment.