益母草注射液联合缩宫素注射液对剖宫产产妇产后出血的预防效果

Effects of Motherwort injection combined with Oxytocin injection in prevention of postpartum hemorrhage in parturients with cesarean section

目的:观察益母草注射液联合缩宫素注射液对剖宫产产妇产后出血的预防效果。方法:选取2020年3月至2023年2月该院收治的182例剖宫产产妇进行前瞻性研究,按照随机数字表法分为研究组与对照组各91例。对照组产后采用缩宫素注射液治疗,研究组在对照组基础上联合益母草注射液治疗,比较两组产后2、24h出血量,住院时间,凝血指标[D-二聚体、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)和纤维蛋白原]水平,丙二醛水平和不良反应发生率。结果:研究组产后2、24 h出血量低于对照组,住院时间短于对照组,差异均有统计学意义(P<0.05);产后24h,两组D-二聚体、纤维蛋白原水平高于产前,且研究组高于对照组,两组PT、APTT、TT短于产前,且研究组短于对照组,差异均有统计学意义(P<0.05);产后24h,两组血清丙二醛水平高于产前,但研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益母草注射液联合缩宫素注射液预防剖宫产产妇产后出血可降低其产后2、24h出血量以及丙二醛水平,缩短其住院时间,改善其凝血指标水平,效果优于单纯缩宫素注射液预防。

Objective:To observe effects of Motherwort injection combined with Oxytocin injection in prevention of postpartum hemorrhage in parturients with cesarean section.Methods:A prospective study was conducted on 182 parturients with cesarean section admitted to the hospital from March 2020 to February 2023.According to the random number table method,they were divided into study group and control group,91 cases in each group.The control group was treated with Oxytocin injection after delivery,while the study group was treated with Motherwort injection on the basis of that of the control group.The amount of bleeding 2h and 24h after delivery,the hospitalization time,the coagulation indexes[D-dimer,activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT)and fibrinogen]levels,the malondialdehyde level,and the incidence of adverse reactions were compared between the two groups.Results:The amount of bleeding 2 h and 24 h after delivery in the study group was lower than that in the control group,the hospitalization time was shorter than that in the control group,and the differences were statistically significant(P<0.05).At 24 h after delivery,the levels of D-dimer and FBG in the two groups were higher than those before delivery,and those in the study group were higher than those in the control group;the PT,APTT and TT levels in the two groups were shorter than those before delivery,those in the study group were shorter than those in the control group;and the differences were statistically significant(P<0.05).At 24 h after delivery,the levels of serum malondialdehyde in the two groups were higher than those before delivery,but that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Motherwort injection combined with Oxytocin injection in the prevention of postpartum hemorrhage in the parturients with cesarean section can reduce the amount of bleeding 2 h and 24 h after delivery and the levels of malondialdehyde,shorten the hospitalization time and improve the levels of coagulation indexes.Moreover,it is superior to single Oxytocin injection prevention.