BIS监测技术指导下丙泊酚靶控输注对结直肠癌根治术患者的影响

Effect of Target-controlled Infusion of Propofol under the Guidance of BIS Monitoring Technology on Colorectal Cancer Patients Undergoing Radical Operation

目的:分析脑电双频指数(BIS)监测技术指导下靶控输注丙泊酚麻醉对结直肠癌根治术患者的影响。方法:选取2022年1月—2023年12月北京丰台医院收治的100例结直肠癌患者,按随机数表法分为两组,各50例。所有患者均行结直肠癌根治术治疗,对照组常规靶控输注丙泊酚麻醉,观察组则在BIS监测技术指导下靶控输注丙泊酚麻醉。比较两组的手术指标、血流动力学指标及应激反应指标等。结果:观察组丙泊酚用量少于对照组,并发症发生率低于对照组,诱导时间、苏醒时间、拔管时间、手术时间短于对照组,差异有统计学意义(P<0.05)。插管时(T_(1))、插管后1 min(T_(2))、建立气腹时(T_(3))、手术结束时(T_(4)),两组心率(HR)、平均动脉压(MAP)均高于麻醉诱导前(T_(0)),但观察组MAP、HR均低于对照组,差异有统计学意义(P<0.05)。术后12 h,两组皮质醇(Cor)、去甲肾上腺素(NE)水平低于术前,肾上腺素(E)水平高于术前,且观察组Cor、NE水平低于对照组,E水平高于对照组,差异有统计学意义(P<0.05)。结论:BIS监测技术指导下靶控输注丙泊酚可有效减少结直肠癌根治术患者的应激反应,维持血流动力学稳定,有利于提高麻醉安全性,降低术后并发症风险。

Objective:To analyze the effect of target-controlled infusion of Propofol under the guidance of bispectral index(BIS)monitoring technology on patients undergoing radical resection of colorectal cancer.Method:A total of 100 patients with colorectal cancer admitted to Beijing Fengtai Hospital from January 2022 to December 2023 were selected and divided into two groups according to random number table method,with 50 patients in each group.All patients underwent radical resection of colorectal cancer.The control group received conventional target-controlled infusion of Propofol,while the observation group received target-controlled infusion of Propofol under the guidance of BIS monitoring technology.The surgical indexes,hemodynamic indexes and stress response indexes were compared between the two groups.Result:The dosage of Propofol in the observation group was lower than that in the control group,the incidence of complications was lower than that in the control group,and the induction time,recovery time,extubation time and surgical time were shorter than those in the control group,the differences were statistically significant(P<0.05).At the time of intubation(T_(1)),1 min after intubation(T_(2)),at the time of pneumoperitoneum establishment(T_(3)),and at the end of operation(T_(4)),the heart rate(HR)and mean arterial pressure(MAP)of the two groups were higher than those pre-induction anesthesia(T_(0)),but the MAP and HR of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).At 12 h after surgery,the levels of cortisol(Cor)and norepinephrine(NE)in two groups were lower than those before surgery,and the level of epinephrine(E)was higher than that before surgery,and the levels of Cor and NE in observation group were lower than those in control group,and the level of E was higher than that in control group,the differences were statistically significant(P<0.05).Conclusion:Targetcontrolled infusion of Propofol under the guidance of BIS monitoring technology can effectively reduce the stress response of patients undergoing radical resection of colorectal cancer,maintain stable hemodynamics,improve the safety of anesthesia and reduce the risk of postoperative complications.