CSU患儿血清维生素D、DHEA-S与Th1/Th2细胞因子及免疫球蛋白的相关性

Correlation of Serum Vitamin D and DHEA-S with Th1/Th2 Cytokines and Immunoglobulin in Children with CSU

目的:探讨慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)患儿维生素D、脱氢表雄酮硫酸酯(dehydroepiandrosterone sulfate,DHEA-S)与Th1/Th2细胞因子及免疫球蛋白的相关性。方法:选取2022年3月—2023年5月深圳市坪山区妇幼保健院收治的73例CSU患儿作为研究组,选取同期体检结果健康的70例儿童作为对照组。检测两组维生素D、DHEA-S、Th1/Th2细胞因子及免疫球蛋白水平。比较两组、轻度、中度及重度CSU患儿维生素D、DHEA-S、Th1/Th2细胞因子及免疫球蛋白水平。分析CSU患儿维生素D、DHEA-S与Th1/Th2细胞因子及免疫球蛋白的相关性。结果:研究组维生素D、DHEA-S、白细胞介素-2(interleukin-2,IL-2)、γ干扰素(interferon-γ,IFN-γ)水平均低于对照组,白细胞介素-4(interleukin-4,IL-4)、免疫球蛋白E(immunoglobulin E,IgE)、免疫球蛋白G(immunoglobulin G,IgG)水平均高于对照组,差异有统计学意义(P<0.05)。中度、重度患儿DHEA-S、IFN-γ水平低于轻度患儿,IgE、IgG水平高于轻度患儿,重度患儿DHEA-S、IFN-γ水平低于中度患儿,IgE、IgG水平高于中度患儿,差异有统计学意义(P<0.05)。维生素D与DHEA-S与IL-2、IFN-γ均呈正相关,与IL-4呈负相关(P<0.05);DHEA-S与IgE呈负相关(P<0.05)。结论:CSU患儿血清维生素D降低同Th1/Th2细胞因子失衡相关,DHEA-S随着病情加重而降低。

Objective:To investigate the association of serum vitamin D,dehydroepiandrosterone sulfate(DHEA-S),Th1/Th2 cytokines,and immunoglobulins in children with chronic spontaneous urticaria(CSU).Method:Seventy-three children with CSU admitted to Shenzhen Pingshan District Maternal and Child Health Hospital from March 2022 to May 2023 were selected as the study group,and 70 children with healthy physical examination results during the same period were selected as the control group.The levels of vitamin D,DHEA-S,Th1/Th2 cytokines and immunoglobulin in the two groups were detected.The levels of vitamin D,DHEA-S,Th1/Th2 cytokines and immunoglobulin between the two groups and in mild,moderate and severe CSU children were compared.The correlation between vitamin D,DHEA-S and Th1/Th2 cytokines and immunoglobulin in CSU children was analyzed.Result:Vitamin D,DHEA-S,interleukin-2(IL-2),interferon-γ(IFN-γ)levels in the study group were lower than those in the control group,and interleukin-4(IL-4),immunoglobulin E(IgE)and immunoglobulin G(IgG)were higher than those of control group,and the differences were statistically significant(P<0.05).The levels of DHEA-S and IFN-γin moderate and severe children were lower than those in mild children,the levels of IgE and IgG were higher than those in mild children,the levels of DHEA-S and IFN-γin severe children were lower in moderate children,and the levels of IgE and IgG were higher than those in moderate children,and the differences were statistically significant(P<0.05).Vitamin D and DHEA-S were positively correlated with IL-2 and IFN-γ,and negatively correlated with IL-4(P<0.05).DHEA-S was negatively correlated with IgE(P<0.05).Conclusion:The decrease of serum vitamin D in children with CSU was associated with the imbalance of Th1/Th2 cytokines,and DHEA-S decreased as the disease worsened.