肥大细胞在内脏高敏疼痛发生机制中作用的研究进展

Research Progress on Role of Mast Cells in the Mechanism of Visceral Hypersensitivity Pain

内脏高敏状态是肠应激综合征(irritable bowel syndrome,IBS)、功能性肛门直肠痛、慢性盆腔疼痛等疾病的常见表现,而疼痛是此类疾病常见的症状之一。目前,内脏高敏疼痛的发生机制尚不明确,也尚无明确有效的治疗方法。目前研究发现,肥大细胞在内脏高敏性疼痛的发生和维持中发挥重要作用。肥大细胞可能通过提高内脏敏感性,以及影响神经内分泌免疫网络从而导致内脏高敏疼痛的发生。因此调节肥大细胞的功能可能成为治疗内脏高敏性疼痛的新途径之一。本文总结了肥大细胞在内脏高敏疼痛发生机制中可能的作用,并基于上述机制对内脏高敏疼痛的治疗作一展望。

Visceral hypersensitivity state is a common manifestation of irritable bowel syndrome(IBS),functional anorectal pain,chronic pelvic pain and other diseases,and pain is one of the common symptoms of such diseases.At present,the mechanism of visceral hypersensitivity pain is not clear,and there is no clear and effective treatment method.Currently,research has found that mast cells play an important role in the occurrence and maintenance of visceral hypersensitivity pain.Mast cells may lead to visceral hypersensitivity pain by increasing visceral sensitivity and affecting the neuroendocrine immune network.Therefore,regulating the function of mast cells may become one of the new ways to treat visceral hypersensitivity pain.This article summarized the possible role of mast cells in the mechanism of visceral hypersensitivity pain and provided a prospect for the treatment of visceral hypersensitivity pain based on the above mechanisms.