布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果

Effect of Budesonide Combined with Vitamin K_(3) Injection in the Treatment of Pediatric Bronchiolitis

目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组采用布地奈德联合维生素K_(3)注射液治疗。比较两组治疗前后白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、γ干扰素(interferon-γ,IFN-γ)炎症因子水平,用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))等肺功能指标及效果。结果:两组治疗前IL-6、CRP、IFN-γ、FVC、FEV_(1)水平比较,差异无统计学意义(P>0.05);观察组治疗后IL-6、CRP水平低于对照组,IFN-γ、FVC、FEV_(1)高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果显著,不仅能有效降低机体炎症因子水平,还能改善肺功能。

Objective:To investigate the effect of Budesonide combined with Vitamin K_(3) Injection in the treatment of bronchiolitis.Method:A total of 70 children with pediatric bronchiolitis who admitted to Qianxi People's Hospital from January December 2022 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 35 cases in each group.The control group was treated with Budesonide,and the observation group was treated with Budesonide combined with Vitamin K_(3) Injection.And the levels of interleukin-6(IL-6),C-reactive protein(CRP),interferon-γ(IFN-γ)inflammatory factors,lung function indexes such as forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))before and after treatment and effects were compared between the two groups.Result:There were no significant differences in the levels of IL-6,CRP,IFN-γ,FVC and FEV_(1)between two groups before treatment(P>0.05);the levels of IL-6 and CRP in the observation group after treatment were lower than those in the control group,and the levels of IFN-γ,FVC and FEV_(1)were higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Budesonide combined with Vitamin K_(3) Injection has a significant effect in the treatment of pediatric bronchiolitis,which can not only effectively reduce the level of inflammatory factors,but also improve lung function.