硝苯地平联合拉贝洛尔在妊娠期高血压中的控压效果及对妊娠结局的影响

Effect of Nifedipine Combined with Labetalol on Gestational Hypertension and Its Influence on Pregnancy Outcome

目的:分析硝苯地平联合拉贝洛尔治疗妊娠期高血压的效果及对妊娠结局的影响。方法:选择2018年4月—2023年12月在石阡县人民医院产科收治的55例妊娠期高血压患者展开研究。根据患者在控压中是否使用硝苯地平将其分为对照组(n=26)和观察组(n=29);对照组使用拉贝洛尔治疗,观察组在对照组基础上联合硝苯地平治疗。比较两组治疗前后血压水平、凝血功能指标、血流动力学指标及不良妊娠事件的发生情况。结果:治疗前,两组血压水平、凝血功能指标、脐动脉血流动力学指标比较,差异无统计学意义(P>0.05)。治疗后,观察组收缩压、舒张压、纤维蛋白原(FIB)水平、脐动脉收缩/舒张末期血流速度比(S/D)、搏动指数(PI)、阻力指数(RI)均低于对照组,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和凝血酶时间(TT)长于对照组,差异有统计学意义(P<0.05)。两组不良妊娠事件发生率比较,差异无统计学意义(P>0.05)。结论:拉贝洛尔联合硝苯地平治疗妊娠期高血压的效果显著,可有效避免不良妊娠事件的发生。

Objective:To analyze the effect of Nifedipine combined with Labetalol on gestational hypertension and its influence on pregnancy outcome.Method:A total of 55 patients with gestational hypertension admitted to the Obstetrics Department of Shiqian County People's Hospital from April 2018 to December 2023 were selected for this study.The patients were divided into control group(n=26)and observation group(n=29)according to whether Nifedipine was used in pressure control.The control group was treated with Labetalol,and the observation group was treated with Nifedipine based on the control group.Blood pressure level,coagulation function index,hemodynamic index before and after treatment and the occurrence of adverse pregnancy events were compared between the two groups.Result:Before treatment,there were no significant differences in blood pressure,coagulation function index and umbilical artery hemodynamics index between the two groups(P>0.05).After treatment,systolic blood pressure,diastolic blood pressure,fibrinogen(FIB)level,umbilical artery systolic/diastolic end-flow velocity ratio(S/D),pulsation index(PI)and resistance index(RI)in the observation group were lower than those in the control group,and prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)in the observation group were longer than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse pregnancy events between the two groups(P>0.05).Conclusion:Labetalol combined with Nifedipine is effective in the treatment of gestational hypertension and can effectively avoid the occurrence of adverse pregnancy events.