生殖道沙眼衣原体和生殖支原体对女性不孕患者性激素及炎症因子的影响

Effects of Chlamydia Trachomatis and Mycoplasma Genitalia in Genital Tract on Sex Hormones and Inflammatory Factors in Female Infertile Patients

目的:生殖道沙眼衣原体和生殖支原体对女性不孕患者性激素、炎症因子的影响。方法:选取2022年1—12月福建医科大学附属三明第一医院收治的76例不孕患者作为观察组,同期入组50例健康查体人群作为对照组。两组均进行病原体检查。观察组进行性激素、炎症因子及抗子宫内膜抗体检查。比较观察组和对照组病原体阳性率。比较观察组感染患者和未感染患者抗子宫内膜抗体阳性率、性激素、炎症因子。结果:观察组生殖道沙眼衣原体和生殖支原体阳性率分别为15.79%和11.84%,明显高于对照组的2.00%和0,差异有统计学意义(P<0.05)。感染患者血清抗子宫内膜抗体阳性率明显高于未感染患者,差异有统计学意义(P<0.05)。感染患者促卵泡生成素、促黄体生成素、雌二醇均明显高于未感染患者,差异有统计学意义(P<0.05)。感染患者白细胞介素-2、肿瘤坏死因子-α水平均明显高于未感染患者,差异有统计学意义(P<0.05)。结论:生殖道沙眼衣原体和生殖支原体感染是导致女性不孕的重要原因,生殖道沙眼衣原体和生殖支原体感染会促进抗子宫内膜抗体的生成,并会影响性激素和炎症因子水平,进而引起不孕。

Objective:To investigate the effects of chlamydia trachomatis and mycoplasma genitalia in genital tract on sex hormones and inflammatory factors in female infertile patients.Method:A total of 76 infertile patients admitted to Sanming First Affiliated Hospital of Fujian Medical University from January to December 2022 were selected as the observation group,and 50 healthy subjects were enrolled during the same period as the control group.Both groups were examined for pathogens.Sex hormones,inflammatory factors and anti-endometrial antibodies were examined in the observation group.The positive rate of pathogens was compared between the observation group and the control group.The positive rate of anti-endometrial antibodies,sex hormones and inflammatory factors were compared between infected and uninfected patients in the observation group.Result:The positive rates of chlamydia trachomatis and mycoplasma genitalia in the observation group were 15.79%and 11.84%,respectively,which were significantly higher than 2.00%and 0 in the control group,and the differences were statistically significant(P<0.05).The positive rate of serum anti-endometrial antibody in infected patients was significantly higher than that in uninfected patients,the differences were statistically significant(P<0.05).Folliclestimulating hormone,luteinizing hormone and estradiol in infected patients were significantly higher than those in uninfected patients,the differences were statistically significant(P<0.05).The levels of interleukin-2 and tumor necrosis factor-αin infected patients were significantly higher than those in uninfected patients,the differences were statistically significant(P<0.05).Conclusion:Infection with chlamydia trachomatis and mycoplasma genitalium in reproductive tract is an important cause of female infertility.Infection with chlamydia trachomatis and mycoplasma genitalium can promote the production of anti-endometrial antibodies and affect the levels of sex hormones and inflammatory factors,thus causing infertility.