左氧氟沙星联合氨溴索治疗老年慢性阻塞性肺疾病合并肺部感染患者的临床效果研究

Study on clinical effect of levofloxacin combined with ambroxol in the treatment of elderly patients with chronic obstructive pulmonary disease complicated with lung infection

目的分析左氧氟沙星联合氨溴索应用于老年慢性阻塞性肺疾病(COPD)合并肺部感染患者中的临床价值。方法选择106例老年COPD合并肺部感染患者并随机均分为观察组和对照组,每组53例。对照组接受左氧氟沙星治疗,观察组增加氨溴索治疗。对比两组患者临床疗效、不良反应发生率及治疗前后炎症因子指标[C反应蛋白(CRP)、降钙素原(PCT)]、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]。结果观察组总有效率94.34%高于对照组的81.13%(P<0.05)。治疗后观察组FEV1(2.70±0.13)L、FVC(3.40±0.39)L高于对照组的(2.63±0.11)、(3.23±0.42)L(P<0.05)。治疗后观察组血清CRP(14.20±1.12)mg/L和PCT(0.86±0.15)ng/ml低于对照组的(15.13±1.57)mg/L、(0.92±0.14)ng/ml(P<0.05)。治疗后,两组SOD均高于治疗前,MDA均低于治疗前,且观察组SOD(95.86±6.09)U/L高于对照组的(84.91±5.65)U/L,MDA(5.45±1.59)μmol/L低于对照组的(6.29±1.48)μmol/L(P<0.05)。两组不良反应发生率比较差异无显著性(P>0.05)。结论对老年慢性阻塞性肺疾病合并肺部感染患者联用左氧氟沙星与氨溴索效果肯定,有助于改善患者肺功能,缓解患者机体炎症反应和氧化应激反应,同时安全性也值得肯定,具有较好的推广应用价值。

Objective Exploring the effect of combining levofloxacin with ambroxol in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods 106 elderly COPD patients with pulmonary infection were selected and randomly divided into an observation group and a control group,with 53 cases in each group.The control group received treatment with levofloxacin,while the observation group received additional treatment with ambroxol.Compare the clinical efficacy,incidence of adverse reactions,and inflammatory cytokine indicators[C-reactive protein(CRP),procalcitonin(PCT)],lung function indicators[forced expiratory volume at 1 second(FEV1),forced vital capacity(FVC)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)]between two groups of patients before and after treatment.Results The total effective rate of 94.34%in the observation group was higher than 81.13%in the control group(P<0.05).After treatment,the FEV1(2.70±0.13)L and FVC(3.40±0.39)L in the observation group were higher than those in the control group(2.63±0.11)and(3.23±0.42)L(P<0.05).After treatment,the serum CRP(14.20±1.12)mg/L and PCT(0.86±0.15)ng/ml in the observation group were lower than those in the control group(15.13±1.57)mg/L and(0.92±0.14)ng/ml(P<0.05);the observation group had higher SOD of(95.86±6.09)U/L than(84.91±5.65)U/L in the control group,and lower MDA of(5.45±1.59)μmol/L than(6.29±1.48)μmol/L in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Elderly patients with chronic obstructive pulmonary disease complicated with lung infection should be treated with a combination of levofloxacin and ambroxol regimen,which helps to improve the lung function of the patients and alleviate the inflammatory response and oxidative stress of the patients'organisms,and its safety is also worthy of affirmation,which is of good value for popularization and application.