非小细胞肺癌MET、KRAS、PIK3CA和BRAF基因突变状态与临床特征的关系分析

Correlation analysis of mutation status of MET,KRAS,PIK3CA and BRAF genes with clinical characteristics in non-small cell lung cancer

目的分析非小细胞肺癌原癌基因(MET)、Kirsten鼠类肉瘤病毒癌基因(KRAS)、磷脂酰肌醇-3-激酶催化亚单位α(PIK3CA)、鼠类肉瘤病毒癌基因同源物B1(BRAF)基因突变状态与临床特征的关系。方法选择719例非小细胞肺癌患者,通过二代测序(NGS)检测患者的MET、KRAS、PIK3CA、BRAF,分析基因突变状态与临床特征的关系。结果MET基因突变的临床特征:男性患者13例,女性患者12例;<60岁患者8例,≥60岁患者17例;腺癌11例,非腺癌14例。KRAS基因突变的临床特征:男性患者15例,女性患者11例;<60岁患者8例,≥60岁患者18例;腺癌14例,非腺癌12例。PIK3CA基因突变的临床特征:男性患者12例,女性患者10例;<60岁患者9例,≥60岁患者13例;腺癌15例,非腺癌7例。BRAF基因突变的临床特征:男性患者11例,女性患者12例;<60岁患者13例,≥60岁患者10例;腺癌12例,非腺癌11例。结论非小细胞肺癌MET、KRAS、PIK3CA、BRAF基因突变状态与临床特征存在一定关系。

Objective To analyze the correlation of mutation status of proto-oncogene(MET),Kirsten rat sarcoma viral oncogene homolog(KRAS),phosphatidylinositol-3-kinase(PIK3CA)and v-raf murine sarcoma viral oncogene homolog B1(BRAF)genes with clinical characteristics in non-small cell lung cancer.Methods 719 patients with non-small cell lung cancer were selected.MET,KRAS,PIK3CA and BRAF of the patients were detected by next generation sequencing(NGS),and the correlation between gene mutation and clinical characteristics was analyzed.Results Clinical characteristics of MET gene mutation:13 male patients and 12 female patients;there were 8 patients<60 years old and 17 patients≥60 years old;there were 11 cases of adenocarcinoma and 14 cases of non-adenocarcinoma.Clinical characteristics of KRAS gene mutation:15 male patients and 11 female patients;there were 8 patients<60 years old and 18 patients≥60 years old;there were 14 cases of adenocarcinoma and 12 cases of non-adenocarcinoma.Clinical characteristics of PIK3CA gene mutation:12 male patients and 10 female patients;there were 9 patients<60 years old and 13 patients≥60 years old;there were 15 cases of adenocarcinoma and 7 cases of non-adenocarcinoma.Clinical characteristics of BRAF gene mutation:11 male patients and 12 female patients;there were 13 patients<60 years old and 10 patients≥60 years old;there were 12 cases of adenocarcinoma and 11 cases of non-adenocarcinoma.Conclusion There is a certain correlation between mutation status of MET,KRAS,PIK3CA and BRAF gene and clinical features in non-small cell lung cancer.