普瑞巴林与加巴喷丁治疗带状疱疹后神经痛的效果比较

Comparative analysis of the effect of pregabalin and gabapentin in the treatment of postherpetic neuralgia

目的比较普瑞巴林与加巴喷丁治疗带状疱疹后神经痛(PHN)的效果与安全性。方法选择72例PHN患者为研究对象,随机分为普瑞巴林组与加巴喷丁组,每组36例。普瑞巴林组在常规治疗的基础上加用普瑞巴林,加巴喷丁组在常规治疗的基础上加用加巴喷丁。比较两组基线及治疗后不同时间点视觉模拟评分法(VAS)评分、睡眠障碍指数(SPI)与不良反应发生情况、临床疗效。结果两组组基线、治疗后3 d VAS评分无统计学差异(P>0.05)。两组患者VAS评分均随着时间推移呈下降趋势,普瑞巴林组治疗后7、14、28及56 d VAS评分分别为(4.0±0.8)、(2.8±0.7)、(2.2±0.6)、(1.6±0.5)分,均显著低于加巴喷丁组的(4.6±1.3)、(3.5±1.1)、(2.8±1.2)、(2.1±0.8)分,差异有统计学意义(P<0.05)。两组基线SPI无统计学差异(P>0.05);两组患者SPI均随着时间推移呈下降趋势,普瑞巴林组治疗后28、56 d SPI分别为(23.3±5.6)、(16.2±4.1)分,均低于加巴喷丁组的(29.4±6.0)、(21.6±5.7)分,差异有统计学意义(P<0.05)。普瑞巴林组与加巴喷丁组有效率分别为94.4%与86.1%,组间比较无统计学差异(P>0.05);普瑞巴林组优良率86.1%显著高于加巴喷丁组的63.9%,差异有统计学意义(P<0.05)。两组头晕、头痛、视物模糊、嗜睡、口干、外周水肿发生率比较无统计学差异(P>0.05)。结论普瑞巴林与加巴喷丁治疗PHN效果显著,但普瑞巴林治疗效果更佳,二者安全性相当。

Objective To compare the effect and safety of pregabalin and gabapentin in the treatment of postherpetic neuralgia(PHN).Methods A total of 72 PHN patients were studied and randomly divided into pregabalin group and gabapentin group,with 36 cases in each group.The pregabalin group was treated with pregabalin on the basis of conventional treatment,and the gabapentin group was treated with gabapentin on the basis of conventional treatment.The visual analog scale(VAS)score and sleep problems index(SPI)at baseline and at different time points after treatment,occurrence of adverse reactions and clinical efficacy were compared between the two groups.Results There was no significant difference in VAS scores at baseline and at 3 d after treatment between the two groups(P>0.05).VAS scores of the two groups showed a decreasing trend over time.VAS scores of the pregabalin group were(4.0±0.8),(2.8±0.7),(2.2±0.6)and(1.6±0.5)points at 7,14,28 and 56 d after treatment,which were significantly lower than(4.6±1.3),(3.5±1.1),(2.8±1.2)and(2.1±0.8)points of the gabapentin group.The difference was statistically significant(P<0.05).There was no significant difference in baseline SPI between the two groups(P>0.05).SPI of the two groups showed a decreasing trend over time.SPI of the pregabalin group were(23.3±5.6)and(16.2±4.1)points at 28 and 56 d after treatment,which were lower than(29.4±6.0)and(21.6±5.7)points of the gabapentin group.The difference was statistically significant(P<0.05).The effective rate of the pregabalin group and the gabapentin group were 94.4%and 86.1%,and there was no statistical difference between groups(P>0.05).The excellent rate of the pregabalin group was 86.1%,which was significantly higher than 63.9%of the gabapentin group,and the difference was statistically significant(P<0.05).There were no significant differences in the incidence of dizziness,headache,blurred vision,lethargy,dry mouth and peripheral edema between the two groups(P>0.05).Conclusion Pregabalin and gabapentin are effective in the treatment of PHN,but pregabalin is more effective in the treatment of PHN,and the safety of the two is comparable.