度洛西汀联合拉莫三嗪治疗抑郁症的临床效果

Clinical Effects of Duloxetine Combined with Lamotrigine in the Treatment of Depression

目的探究度洛西汀联合拉莫三嗪治疗抑郁症的临床效果。方法选取2022年1月—2023年1月收治的抑郁症95例,采用随机数字表法随机将其分为对照组(47例)、研究组(48例)。对照组给予度洛西汀治疗,研究组给予度洛西汀联合拉莫三嗪治疗,均持续治疗3个月。比较2组治疗效果、单胺类神经递质[多巴胺(DA)、去甲肾上腺素、5-羟色胺(5-HT)]、内分泌激素[促肾上腺皮质激素、皮质醇(CS)、促肾上腺皮质激素释放激素(CRH)]、抑郁症状[抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)]、认知功能[蒙特利尔认知评估量表(MoCA)]及不良反应。结果研究组临床总有效率91.67%(44/48)高于对照组74.47%(35/47)(P<0.05);治疗1、3个月后,与对照组比较,研究组血清5-HT、CRH水平升高,血清DA、CS水平降低(P<0.05)。治疗1、3个月后,研究组SDS、HAMD评分低于对照组,MoCA评分高于对照组(P<0.05)。2组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论度洛西汀联合拉莫三嗪治疗抑郁症能显著增强临床效果,且具有一定安全性。

Objective To investigate the clinical effects of Duloxetine combined with Lamotrigine in the treatment of depression.Methods Ninety-five patients with depression admitted from January 2022 to January 2023 were divided into control group(n=47)and research group(n=48)according to random number table method.The control group was treated with Duloxetine,and the research group was treated with Duloxetine combined with Lamotrigine for 3 months.The therapeutic effects,monoamine neurotransmitters[dopamine(DA),norepinephrine,5-hydroxytryptamine(5-HT)],endocrine hormones[adrenocorticotrophic hormone,cortisol(CS),adrenocorticotropin releasing hormone(CRH)],depressive symptoms[Self-rating Depression Scale(SDS),and Hamilton depression scale(HAMD)score],cognitive function[Montreal Cognitive Assessment Scale(MoCA)]score and adverse reactions were compared between the two groups.Results The total clinical effective rate of the research group was 91.67%(44/48),which was higher than that of the control group[74.47%(35/47)](P<0.05).At 1 and 3 months after treatment,compared with the control group,the levels of serum 5-HT and CRH in the research group were increased,while the levels of serum DA and CS were decreased(P<0.05).At 1 and 3 months after treatment,the scores of SDS and HAMD in the research group were lower than those in the control group,and the scores of MoCA were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusion Duloxetine combined with Lamotrigine in the treatment of depression can significantly enhance the clinical effect,and has a certain safety.