排石汤联合间苯三酚在肾结石钬激光碎石术后的应用效果及对炎性因子、肾功能指标的影响

Application Effect of Paishi Decoction Combined with Phloroglucinol on Renal Calculus after Holmium LaserLithotripsy and Its Impact on Renal Function and Renal Function Indexes

目的探讨排石汤联合间苯三酚在肾结石钬激光碎石术后的应用效果及对炎性因子、肾功能指标的影响。方法选取2021年1月—2023年1月收治的行肾结石钬激光碎石术的肾结石200例,采用随机数字表法随机将其分为研究组和对照组2组各100例。研究组给予排石汤联合间苯三酚治疗,对照组给予间苯三酚治疗。比较2组临床疗效、术后情况、炎性因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和前列腺素E_(2)(PGE_(2))]、肾功能指标[血肌酐(Scr)、尿素(BUN)、胱抑素C(CysC)]及并发症、复发情况。结果治疗7 d后,研究组总有效率为96.00%(96/100)高于对照组81.00%(81/100)(P<0.01)。研究组术后带管不适程度低于对照组,术后拔管时间短于对照组(P<0.01)。治疗7 d后,2组IL-2、IL-6、TNF-α、PGE_(2)和Scr、BUN、CysC均低于治疗前,且研究组低于对照组(P<0.01)。受试期间,研究组并发症总发生率为5.00%(5/100)低于对照组15.00%(15/100)(P<0.05)。随访6个月,研究组复发率为1.02%(1/98)低于对照组11.46%(11/96)(P<0.01)。结论排石汤联合间苯三酚应用于肾结石钬激光碎石术后患者疗效显著,可缩短术后拔管时间,减轻排石时痛苦程度,抑制机体内炎性因子释放,减轻对肾功能损伤,降低并发症发生率和复发率。

Objective To investigate the application effect of Paishi decoction combined with Phloroglucinol on renal calculus after holmium laser lithotripsy(HL)and its effect on inflammatory factors and renal function indexes.Methods A total of 200 patients with renal calculus treated with HL from January 2021 to January 2023 were randomly divided into research group(n=100)and control group(n=100)by random number table method.The research group was treated with Paishi decoction combined with Phloroglucinol,and the control group was treated with Phloroglucinol.The clinical efficacy,postoperative conditions,inflammatory factors[interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and prostaglandin E_(2)(PGE_(2))],renal function indexes[serum creatinine(Scr),blood urea nitrogen(BUN),cystatin C(CysC)],complications and recurrence were compared between the two groups.Results At 7 d after treatment,the total effective rate was 96.00%(96/100)in the research group,which was higher than that[81.00%(81/100)]in the control group(P<0.01).The degree of postoperative discomfort with catheterization in the research group was lower than that of the control group,and the time to extubation was shorter than that of the control group(P<0.01).At 7 d after treatment,IL-2,IL-6,TNF-α,PGE_(2),Scr,BUN and CysC in the two groups were lower than those before treatment,and lower in the research group than in the control group(P<0.01).The total complication rate of the research group was 5.00%(5/100),which was lower than that of the control group[15.00%(15/100)](P<0.05).At 6 months after followup,the recurrence rate of the research group was 1.02%(1/98),which was lower than that of the control group[11.46%(11/96)](P<0.01).Conclusion Paishi decoction combined with Phloroglucinol has significant efficacy in patients with renal calculus after HL,which can shorten the time to extubation,reduce the pain during stone removal,inhibit the release of inflammatory factors in the body,reduce the damage to renal function,and reduce the incidence of complications and recurrence.