大剂量丙种球蛋白、阿司匹林联合甲泼尼龙治疗小儿川崎病的效果分析

Effect Analysis of High-Dose Gamma Globulin Combined and Aspirin with Methylprednisolone in Treatment of Children with Kawasaki Disease

目的:分析大剂量丙种球蛋白、阿司匹林联合甲泼尼龙治疗小儿川崎病的效果。方法:选取2018年10月—2022年10月兰州市西固区人民医院收治的小儿川崎病患者80例作为研究对象,依据随机数字表法分为对照组与试验组,各40例。对照组给予丙种球蛋白、阿司匹林治疗,试验组在对照组基础上应用甲泼尼龙治疗。比较两组治疗效果。结果:试验组治疗总有效率高于对照组,差异有统计学意义(P=0.013)。试验组黏膜充血改善时间、手足水肿改善时间、淋巴结消退时间、高热改善时间早于对照组,住院时间短于对照组,差异有统计学意义(P<0.001)。治疗后,两组白细胞计数、红细胞沉降率、C反应蛋白水平低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。结论:大剂量丙种球蛋白、阿司匹林联合甲泼尼龙治疗小儿川崎病的效果显著,能够促进症状恢复,缩短住院时间,改善实验室检查指标,值得临床推广。

Objective:To analyze the effect of high-dose gamma globulin and Aspirin combined with methylprednisolone in treatment of children with Kawasaki disease.Methods:A total of 80 patients with Kawasaki disease admitted to Xigu District People's Hospital of Lanzhou City from October 2018 to October 2022 were selected as the study subjects.They were divided into the control group and the experimental group according to random number table method,with 40 cases in each group.The control group was treated with gamma globulin,and the experimental group was treated with methylprednisolone on the basis of the control group.The treatment effects of the two groups were compared.Results:The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P=0.013).The time of mucosal congestion improvement,hand and foot edema improvement,lymph node regression and hyperpyrexia improvement in the experimental group was earlier than that in the control group,and the length of hospital stay in the experimental group was shorter than that in the control group,and the difference was statistically significant(P<0.001).After treatment,the white blood cell count,erythrocyte sedimentation rate and C-reactive protein levels in the two groups were lower than those before treatment,and these indicators in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:High-dose gamma globulin and Aspirin combined with methylprednisolone is significantly effective in treatment of children with Kawasaki disease,and can promote the recovery of symptoms,shorten the length of hospital stay,and improve the clinical laboratory indicators,which can be clinically popularized.