不同性别患者精神分裂症症状与健康相关的生命质量比较

Comparison of Symptoms and Health-related Quality of Life in Patients with Schizophrenia of Different Genders

目的:检验精神分裂症患者的HRQoL是否存在性别差异,并探讨性别与精神分裂症症状和HRQoL之间的关系。方法:选择2020年6月至2022年4月来本院门诊接受治疗的1315名精神分裂症患者为研究对象,用PANSS量表进行症状评估,用SF-36、EQ-5D及SQLS进行HRQoL相关评估,并对影响HRQoL的症状的性别差异进行比较。结果:PANSS焦虑抑郁症状、阳性症状、阴性症状与HRQoL之间的相关性较高。女性中,较高的阴性症状评分和焦虑抑郁症状评分与较高的SQLS、较低的SF-36、EQ-5D评分相关;在男性中,较高的阳性症状评分和焦虑抑郁症状评分与较高的SQLS、较低的SF-36、EQ-5D评分相关。结论:男性精神分裂症患者的HRQoL要高于女性。阴性症状、焦虑抑郁症状对女性HRQoL影响较大,阳性症状、焦虑抑郁症状对男性HRQoL影响较大。

Objective:To examine whether there are gender differences in HRQoL in patients with schizophrenia,and to explore the relationship between gender and symptoms of schizophrenia and HRQoL.Method:1315 schizophrenia patients who received treatment in our outpatient department from June 2020 to April 2022 were selected as the research subjects.Use PANSS scale for symptom assessment,SF-36,EQ-5D,and SQLS for HRQoL related assessment,and compare gender differences in symptoms that affect HRQoL.Result:There is a high correlation between PANSS anxiety and depression symptoms,positive symptoms,negative symptoms,and HRQoL.Among women,higher negative symptom scores and anxiety and depression symptom scores are associated with higher SQLS,lower SF-36,and EQ-5D scores.In males,higher positive symptom scores and anxiety and depression symptom scores are associated with higher SQLS,lower SF-36,and EQ-5D scores.Conclusion:The HRQoL of male patients with schizophrenia is higher than that of females.Negative symptoms,anxiety and depression symptoms have a greater impact on female HRQoL,while positive symptoms,anxiety and depression symptoms have a greater impact on male HRQoL.