中医药治疗慢性疲劳综合征研究进展

Research Progress of TCM in the Treatment of Chronic Fatigue Syndrome

中医药治疗慢性疲劳综合征的方法主要包括中医内治法、中医外治法和联合治疗。目前,中医药治疗CFS的研究仍存在以下问题:(1)临床病例样本量过少,缺乏对患者治疗后期的随访,影响研究的可信度;(2)诊断缺乏明确的诊断标志物作为金标准;(3)治疗效果评判多采用量表评分,缺乏统一客观的疗效判定标准;(4)现研究主要从免疫、炎症、氧化损伤等角度进行机理探究,相关机理仍尚未明确。在今后的研究中,应增加病例观察数量,重视回顾性研究,提高随访率,统一诊断和疗效判定标准,加强对相关机制的研究,以期阐明药物及外治法的作用机理,丰富循证医学依据,推动中医药在治疗CFS领域的应用和发展。

The methods of TCM for the treatment of chronic fatigue syndrome(CFS)mainly include internal therapies,external therapies and combined therapies.However,at present,there are still the following problems:(1)The sample size of clinical cases is too small,lack of follow⁃up of patients after treatment,affecting the credibility of the study;(2)The diagnosis lacks a clear diagnostic marker as the gold standard;(3)The evaluation of treatment effect is mostly scale score,lack of unified objective criteria for therapeutic effect.(4)The current study mainly explores the mechanism from the perspectives of immunity,inflammation,oxidative damage,and the rele⁃vant mechanism is still not clear.In future research,the number of observation cases should be increased,attention should be paid to retrospective studies,follow⁃up rate should be improved,unified diagnostic and therapeutic criteria should be established,and the re⁃search on relevant mechanisms should be strengthened,so as to clarify the mechanism of drugs and external therapy,enrich the basis of evidence⁃based medicine,and promote the application and development of TCM in the field of CFS treatment.