肺部微生物组与早产儿支气管肺发育不良

Lung microbiome and bronchopulmonary dysplasia in preterm infants

支气管肺发育不良是早产儿最常见的慢性肺疾病,其病因和发病机制复杂,目前尚未完全明确。近十年来,随着肺部被证明有其独特的肺部微生物群,肺部微生物与支气管肺发育不良受到人们的广泛关注。本文就肺部微生物组的建立及其影响因素、肺部微生物组与支气管肺发育不良的关联进行评述,并对未来研究方向进行展望。

Bronchopulmonary dysplasia is the most common chronic lung disease in preterm infants,with a complex etiology and pathogenesis that is not fully defined.In the last decade,the lung microbes and bronchopulmonary dysplasia have received widespread attention as the lungs have been shown to have their own unique lung microbiota.This paper comments on the establishment of the lung microbiome and its influencing factors,the association between the lung microbiome and bronchopulmonary dysplasia,and discusses the future research directions.