结直肠腺瘤与血脂水平相关性分析:一项单中心回顾性研究

Analysis of correlation between colorectal adenoma and serum lipid level

目的本研究旨在探讨结直肠腺瘤的发生发展与血脂及脂蛋白水平的关系,为结直肠癌的预防提供参考。方法本研究回顾性分析了2018年5月至2020年5月于梅州市人民医院确诊的2960例结直肠腺瘤患者和同期3156名非结直肠腺瘤患者的血脂水平及临床资料。采用Logistic回归分析血脂异常与结直肠腺瘤发生的关系。结果与对照组相比,结直肠腺瘤患者血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和载脂蛋白B(ApoB)水平显著升高,血脂异常发生率明显上升。Logistic回归分析显示,血清中TC和TG水平与结直肠腺瘤风险呈正相关。结论血清TG和TC水平升高是腺瘤的独立危险因素,并且腺瘤患者血清TG和TC水平升高时,可能更容易发展成高危腺瘤。

Objective To investigate the relationship between serum lipid profiles and colorectal adenomas,and to benefit the prevention of colorectal cancer.Methods This study retrospectively analyzes the serum lipid profiles and clinical parameters of 2,960 patients who were diagnosed with colorectal adenomas,and 3,156 individuals without colorectal adenomas in Meizhou People′s Hospital from May 2018 to May 2020.The association between serum lipid profiles and colorectal adenoma was evaluated by Logistic regression analysis.Results It was observed that the serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and apoliprotein B(ApoB)were significantly elevated in patients with colorectal adenomas.Dyslipidemia was more prevalent in adenoma cases than in controls.The Logistic regression analysis suggested that serum TC and TG levels were positively associated with the occurrence of colorectal adenomas.Conclusion Elevated serum TG and TC levels are independent risk factors for adenoma,and adenoma patients with elevated serum TG and TC levels may be more likely to develop high-risk adenoma.