门冬胰岛素30联合格列喹酮对2型糖尿病患者糖脂代谢指标的影响

Effects of Insulin Aspart 30 Combined with Gliquidone on Glucose and Lipid Metabolism Indexes in Patients with Type 2 Diabetes Mellitus

目的:探究门冬胰岛素30联合格列喹酮对2型糖尿病(T2DM)患者糖脂代谢指标的影响。方法:选取2021年5月—2022年5月平和县医院收治的80例T2DM患者,按随机数表法分为两组,各40例。对照组采用门冬胰岛素30治疗,观察组在此基础上加用格列喹酮治疗。比较两组治疗前、治疗12周后的糖脂代谢指标[空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)]、胰岛素抵抗指数(HOMA-IR)及不良反应发生率。结果:治疗12周后,两组FBG、2 h PG、HbA1c、TC及HOMA-IR均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:门冬胰岛素30联合格列喹酮可改善T2DM患者的糖脂代谢水平,降低其HOMA-IR,且不增加不良反应。

Objective:To explore the effects of Insulin Aspart 30 combined with Gliquidone on glucose and lipid metabolism indexes in type 2 diabetes mellitus(T2DM)patients.Method:A total of 80 T2DM patients admitted to Pinghe County Hospital from May 2021 to May 2022 were selected and divided into two groups according to random number table method,with 40 cases in each group.The control group was treated with Insulin Aspart 30,and the observation group was treated with Gliquidone.Glucose and lipid metabolism indexes[fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PG),glycosylated hemoglobin(HbA1c),total cholesterol(TC)],insulin resistance index(HOMA-IR)and incidence of adverse reactions were compared between the two groups before treatment and 12 weeks after treatment.Result:After 12 weeks of treatment,FBG,2 h PG,HbA1c,TC and HOMA-IR in both groups were lower than those before treatment,and which in observation group were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Insulin Aspart 30 combined with Gliquidone can improve glucose and lipid metabolism and reduce HOMA-IR in T2DM patients without increasing adverse reactions.