肺癌诊疗相关的研究进展

Research Progress in Diagnosis and Treatment of Lung Cancer

近年来,随着靶向治疗、免疫治疗、基因检测、人工智能(artificial intelligence,AI)和介入技术的应用,肺癌在早期筛查和治疗方面有所改善,5年生存率已经明显有所提高,然而由于晚期并发症的出现,仍有大部分患者未能获得有效治疗,导致他们未能抓住治疗的最佳时期,这使得肺癌成为全球发病和死亡率都很高的恶性肿瘤,对人类的生活和健康构成极其威胁。大多数晚期肺癌患者接受了有效的治疗后会出现放化疗并发症、对药物耐药及心理和经济上的负担。本文综述目前在肺结节的筛查与管理、肺癌化疗与靶向药物、免疫治疗及肺癌介入等方面的研究进展,为临床实践工作做出一定的指导意义。

In recent years,with the application of targeted therapy,immunotherapy,gene detection,artificial intelligence(AI)and interventional techniques,lung cancer has been improved in early screening and treatment,and the 5-year survival rate has been significantly improved,however,due to the emergence of advanced complications,most patients still fail to obtain effective treatment,resulting in their failure to seize the best time for treatment,which makes lung cancer a malignant tumor with high morbidity and mortality worldwide,posing an extremely threat to human life and health.Most patients with advanced lung cancer will have complications of radiotherapy and chemotherapy,drug resistance and psychological and economic burdens after receiving effective treatment.This article reviewed the current research progress in the screening and management of pulmonary nodules,lung cancer chemotherapy and targeted drugs,immunotherapy and lung cancer intervention,and made some guiding significance for clinical practice.