CT纹理分析对胃癌组织病理特征的术前评估价值

Value of CT Texture Analysis in Preoperative Evaluation of Pathological Characteristics of Gastric Cancer Tissue

目的探究CT纹理分析对胃癌组织病理特征的术前评估价值。方法回顾性分析本院2021年3月~2023年3月本院收治的103例胃癌患者资料,患者在手术治疗前均接受CT检查,并采用纹理分析软件获取患者动脉以及静脉期CT纹理参数,并比较不同TNM分期患者纹理参数差异,采用受试者工作特征(ROC)曲线评估纹理参数对胃癌分期的诊断效能。结果动脉期以及门脉期T_(1-2)组与T_(3-4)组平均值比较差异无统计学意义(P>0.05),但T_(3-4)组峰度值、熵值均显著高于T_(1-2)组,偏度值低于T_(1-2)组(P<0.05)。动脉期以及门脉期N0组与N_(1-3)组平均值、偏度值比较差异无统计学意义(P>0.05),但N_(1-3)组峰度值、熵值显著高于N0组(P<0.05)。动脉期CT纹理峰度值、偏度值、熵值诊断T分期的AUC为0.755、0.955及0.747(P<0.05),门脉期CT纹理峰度值、偏度值、熵值诊断T分期的AUC为0.959、0.871及0.872(P<0.05)。动脉期CT纹理峰度值、偏度值诊断N分期的AUC为0.899、0.702(P<0.05),门脉期CT纹理峰度值、偏度值诊断N分期的AUC为0.924、0.758(P<0.05)。结论CT纹理分析对胃癌TNM分析诊断评估效果良好,可用于临床指导胃癌患者治疗。

Objective To investigate the value of CT texture analysis in preoperative evaluation of pathological characteristics of gastric cancer tissue.Methods The data of 103 gastric cancer patients admitted to the hospital from March 2021 to March 2023 were analyzed retrospectively.All patients received CT examination before surgical treatment,and CT texture parameters in arterial phase and venous phase were obtained using texture analysis software.The texture parameters of patients in different TNM stages were compared,and the performance of texture parameters in gastric cancer staging was evaluated using the receiver operating characteristic(ROC)curve.Results There were no statistically significant differences in mean values between the T_(1-2)group and the T_(3-4)group in arterial phase or portal phase(P>0.05).Kurtosis and entropy of the T_(3-4)group were significantly higher than those of the T_(1-2)group,and the skewness was lower than that of the T_(1-2)group(P<0.05).There was no statistically significant difference in mean value or skewness between the N0 group and the N_(1-3)group in arterial phase or portal phase(P>0.05).Kurtosis and entropy of the N_(1-3)group were significantly higher than those of the N0 group(P<0.05).The AUC values of CT texture kurtosis,skewness and entropy in arterial phase for diagnosing T stage were 0.755,0.955 and 0.747(P<0.05).The AUC values of the three parameters in portal phase for diagnosing T stage were 0.959,0.871 and 0.872(P<0.05).The AUC values of CT texture kurtosis and skewness in arterial phase for diagnosing N stage were 0.899 and 0.702(P<0.05).The AUC values of CT texture kurtosis and skewness in portal phase for diagnosing N stage were 0.924 and 0.758(P<0.05).Conclusion CT texture analysis has good effects in TNM staging of gastric cancer,and can be used to guide the treatment of gastric cancer in clinical practice.