恩格列净对射血分数保留型心力衰竭患者运动耐量的改善效果研究

Study on the Improvement Effect of Englizin on Exercise Tolerance in Patients with Ejection Fraction Preserving Heart Failure

目的观察恩格列净治疗射血分数保留型心力衰竭(HEpEF)的效果及对运动耐量改善的影响。方法前瞻性地选取2020年6月至2023年6月我院收治的73例HEpEF患者作为研究对象。根据数字随机表法随机分成给予沙库巴曲缬沙坦(36例,对照组)和恩格列净+沙库巴曲缬沙坦(37例,观察组)。对比疗效、运动耐量[代谢当量、峰值摄氧量(PeakVO_(2))、通气二氧化碳当量斜率(VE/VCO_(2)slope)]、生活质量[明尼苏达心力衰竭生活质量问卷(MLHFQ)]和安全性。结果观察组显效率56.76%(21/37),高于对照组的33.33%(12/36)(P<0.05)。观察组代谢当量、PeakVO_(2)、VE/VCO_(2)slope治疗前后差值均高于对照组(P<0.05)。观察组MLHFQ评分身体领域、情绪领域、其他领域治疗前后差值均高于对照组(P<0.05)。两组HEpEF患者安全性无差异(P>0.05)。结论恩格列净治疗HEpEF可提高运动耐量改善效果,并提升预后效果,且安全性可靠。

Objective To observe the effect of englaglitzin on the treatment of ejection fraction preserving heart failure(HEpEF)and the improvement of exercise tolerance.Methods A total of 73 HEpEF patients admitted to our hospital from June 2020 to June 2023 were prospectively selected as the study objects.According to the numerical random table method,they were randomly divided into the administration of sacubactril valsartan(36 cases,control group)and englaglitzin plus sacubactril valsartan(37 cases,observation group).Efficacy,exercise tolerance[metabolic equivalent,peak oxygen uptake(PeakVO_(2)),ventilate carbon dioxide equivalent slope(VE/VCO_(2)slope)],quality of life[Minnesota Heart Failure Quality of Life Questionnaire(MLHFQ)],and safety were compared.Results The significant efficiency of observation group was 56.76%(21/37),which was higher than that of control group 33.33%(12/36)(P<0.05).The differences of metabolic equivalent,PeakVO_(2)and VE/VCO_(2)slope before and after treatment in observation group were higher than those in control group(P<0.05).The difference of MLHFQ score in body field,emotional field and other fields before and after treatment in observation group was higher than that in control group(P<0.05).There was no difference in safety between the two HEpEF groups(P>0.05).Conclusions The treatment of HEpEF with englabrazin can improve exercise tolerance and improve prognosis,and is safe and reliable.