双组份系统调控禽致病性大肠杆菌生物被膜的研究进展

Research progress on the regulation of biofilm formation in avian pathogenic Escherichia coli by two-component systems

禽致病性大肠杆菌是一种典型的肠道外致病性大肠杆菌,能够引起各种肠道外疾病,给禽类养殖业造成重大的经济损失。生物被膜作为一种保护细菌的物理屏障用于抵御抗生素的损伤及逃避宿主的免疫系统,从而导致宿主持续和反复性感染。双组份系统是普遍存在于各类细菌中主要的信号传导系统,参与调控细菌抗生素耐药性和生物被膜的形成。为了解由生物被膜造成的禽致病性大肠杆菌感染机制,文章详述了生物被膜的形成过程,并综述了双组份系统调控生物被膜形成的分子机制,以期探寻阻断双组份系统信号转导的新方法以破坏生物被膜的形成作为控制禽致病性大肠杆菌感染的治疗策略,从而为防治由生物被膜引起的抗生素耐药性以及持续或反复性感染提供研究方向。

Avian pathogenic Escherichia coli is a typical extraintestinal pathogenic Escherichia coli that can cause various extraintestinal diseases,leading to significant economic losses in the poultry farming industry.Biofilm,serving as a physical barrier to protect bacteria from antibiotic damage and immune system evasion,contributes to persistent and recurrent infections in hosts.Two-component systems are prevalent signal transduction systems in various bacteria,playing a crucial role in regulating bacterial antibiotic resistance and biofilm formation.To understand the mechanisms of avian pathogenic Escherichia coli infection caused by biofilm,the article elaborates on the process of biofilm formation and provides a comprehensive review of the molecular mechanisms by which two-component systems regulate biofilm formation.The goal is to explore new approaches to disrupt biofilm formation by blocking two-component system signal transduction as a therapeutic strategy for controlling avian pathogenic Escherichia coli infections.The research direction aims to contribute to the prevention and treatment of antibiotic resistance caused by biofilm and persistent or recurrent infections.