补气凉血汤联合卡前列素氨丁三醇对宫缩乏力性产后出血的效果及对氧化应激的影响

Effect of Tonifying Qi and Cooling Blood Decoction Combined with Carboprost Tromethamine on Postpartum Hemorrhage Caused By Uterine Atony and Its Effect on Oxidative Stress

目的 探讨补气凉血汤联合卡前列素氨丁三醇对宫缩乏力性产后出血的效果及对氧化应激的影响。方法 纳入2022年1—12月本院收治的宫缩乏力性产后出血患者共90例,采用随机数字表法分为对照组(45例)和试验组(45例),分别给予卡前列素氨丁三醇治疗和补气凉血汤联合卡前列素氨丁三醇治疗;比较两组治疗总有效率、出血量、出血持续时间、产后出血相关并发症发生率、治疗前后超氧化物歧化酶、脂质过氧化物及谷胱甘肽过氧化物酶水平。结果 试验组治疗总有效率显著高于对照组(P<0.05);试验组出血量和出血持续时间均显著少于对照组;试验组后期出血和产褥感染发生率显著低于对照组(P<0.05);两组治疗后超氧化物歧化酶显著高于治疗前(P<0.05);两组治疗后脂质过氧化物和谷胱甘肽过氧化物酶水平均显著低于治疗前(P<0.05);但试验组治疗后超氧化物歧化酶、脂质过氧化物及谷胱甘肽过氧化物酶水平均显著优于对照组(P<0.05)。结论 补气凉血汤联合卡前列素氨丁三醇治疗宫缩乏力性产后出血可有效促进子宫收缩,控制出血量,缩短出血时间,降低产后出血相关并发症发生率,并有助于调节机体氧化应激水平。

Objective To explore effect of tonifying qi and cooling blood decoction combined with carboprost tromethamine on postpartum hemorrhage caused by uterine atony and its effect on oxidative stress.Methods The paper chose 90 patients with postpartum hemorrhage caused by uterine atony admitted to our hospital from January 2022 to December 2022,and divided them into control group(45 cases) and experimental group(45 cases) with random number table mehtod,treated with carboprost tromethamine and tonifying qi and cooling blood decoction combined with carboprost tromethamine respectively.Total effective rate,bleeding volume,bleeding duration,incidence of postpartum hemorrhage related complications,and levels of superoxide dismutase,lipid peroxide,and glutathione peroxidase were compared before and after treatment between two groups.Results The total effective rate of experimental group was 95.56%,significantly higher than 77.78%in control group(P< 0.05).Bleeding amount and duration in experimental group was significantly lower than control group.Incidence of bleeding and postpartum infection in experimental group was significantly lower than control group(P< 0.05).After treatment,levels of superoxide dismutase in both groups were significantly higher than before treatment(P<0.05).After treatment,levels of lipid peroxides and glutathione peroxidase in both groups were significantly lower than before treatment(P< 0.05).However,levels of superoxide dismutase,lipid peroxide,and glutathione peroxidase in experimental group were significantly higher than control group after treatment(P<0.05).Conclusion Combination of tonifying qi and cooling blood decoction and carboprost tromethamine can promote uterine contractions effectively,control bleeding volume,shorten bleeding time,reduce incidence of postpartum hemorrhage related complications,and regulate oxidative stress level of the body in treatment of postpartum hemorrhage caused by uterine atony.