泮托拉唑与奥曲肽联用对上消化道溃疡合并出血患者疗效的影响

Effect of Pantoprazole Combined with Octreotide on Patients with Upper Gastrointestinal Ulcer Complicated with Bleeding

目的 分析泮托拉唑联合奥曲肽治疗上消化道溃疡合并出血的效果。方法 本研究以徐州矿务集团第一医院、第二医院消化内科在2018年9月—2023年7月收治的60例患有上消化道溃疡并发出血的患者为研究对象,随机分为对照组与试验组,每组30例,在常规治疗的基础上,对照组用奥曲肽单药物治疗,试验组使用泮托拉唑联合奥曲肽治疗,两组患者均连续治疗7d,比较两组患者治疗前与治疗后的治疗效果,血清血红蛋白、网织红细胞、尿素氮水平和不良反应发生率。结果 试验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的血红蛋白水平、网织红细胞和尿素氮值在组内和组间比较以及交互作用方面,差异有统计学意义(P<0.05)。治疗后,试验组血红蛋白、网织红细胞、尿素氮值高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应的发生率低,两组间差异无统计学意义(P>0.05),提示两种药物联用对消化道出血病人的安全性较好。结论 泮托拉唑联合奥曲肽对上消化道溃疡合并出血的效果显著,可以有效控制出血,不良反应事件发生率小,安全性好。

Objective To analyze the effect of Pantoprazole combined with octreotide in the treatment of upper gastrointestinal ulcer complicated with bleeding.Methods In this study,60patients with upper digestive tract ulcer complicated with bleeding admitted to the Department of Gastroenterology of the First Hospital and the Second Hospital of Xuzhou Mining Group from September 2018 to July 2023 were randomly divided into control group and experimental group with 30 cases each.On the basis of conventional treatment,the control group was treated with octreotide monotherapy.The experimental group was treated with Pantoprazole combined with octreotide,and the two groups were treated for 7 consecutive days.The therapeutic effect,serum hemoglobin,reticulocyte,urea nitrogen levels and the incidence of adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the experimental group was 90% higher than that of the control group(73.33%),with statistical significance(P< 0.05).After treatment,there were statistically significant differences in hemoglobin level,reticulocyte and urea hydrogen value between two groups in comparison and interaction between groups(P< 0.05).Compared with control group,the hemoglobin,reticulocyte and urea nitrogen values of experimental groups were higher than those of control group after treatment,with statistical differences(P<0.05).The incidence of adverse reactions in the two groups was low,and there was no statistical difference between the two groups(P>0.05),suggesting that the combined use of the two drugs is safe for patients with digestive tract bleeding.Conclusion Pantoprazole combined with octreotide has a significant effect on upper gastrointestinal ulcer complicated with bleeding,which can effectively control bleeding,with a small incidence of adverse events and good safety.