研究针灸联合美沙拉嗪治疗脾肾阳虚型溃疡性结肠炎的临床疗效

Clinical Effect Research of Acupuncture Combined with Mesalazine on Ulcerative Colitis of Spleen Kidney Yand Deficiency Type

目的 分析针灸联合美沙拉嗪治疗脾肾阳虚型溃疡性结肠炎的临床疗效。方法 选取2020年10月—2022年10月本院收治的70例脾肾阳虚型溃疡性结肠炎患者为研究对象,根据治疗方法的不同,分为观察组(n=35)和对照组(n=35)。给予对照组美沙拉嗪治疗,观察组在前者基础上辅以针灸治疗。对比两组治疗前后的中医症状积分、血清炎性因子水平、细胞免疫平衡指标以及治疗效果。结果 观察组治疗后的腹部冷痛、畏寒肢冷、晨起泄泻三个维度的中医症状积分均低于对照组(P<0.05);观察组治疗后的IFN-γ、5-HT、SP、HIS水平均低于对照组,IL-4、IL-10、VIP水平均高于对照组(P<0.05);观察组治疗后的Th17细胞、Th17/Treg比值均低于对照组,Treg比值高于对照组(P<0.05);观察组治疗有效率高于对照组(P<0.05)。结论 在脾肾阳虚型溃疡性结肠炎治疗中,相较于单一疗法,联合疗法的治疗效果更加确切,能够快速减轻患者的炎症反应,改善患者的临床症状,加快患者康复进程。

Objective To analyze clinical effect of acupuncture combined with mesalazine in treatment of ulcerative colitis of spleen kidney Yand deficiency type.Methods The paper chose 70patients with ulcerative colitis of spleen kidney Yand deficiency type admitted to our hospital from October 2020 to October 2022,and divided them into observation group(n=35) and control group(n=35) according to different treatment methods.Control group was treated with mesalazine,and observation group with acupuncture on the basis of the former.Traditional Chinese medicine symptom scores,serum inflammatory factor levels,cellular immune balance indicators,and treatment effect were compared between two groups before and after treatment.Results TCM symptom scores of abdominal cold pains,chills in limbs,and morning diarrhea in observation group were lower than control group after treatment(P< 0.05).Levels of IFN-γ,5-HT,SP and HIS in observation group were lower than control group after treatment,while levels of IL-4,IL-10 and VIP were higher than control group(P<0.05).After treatment,Th17 cells and Th17/Treg ratio in observation group was lower than control group,Treg ratio was higher than control group(P<0.05).Effective rate of treatment in observation group was 94.29%,higher than 74.29% in control group(P< 0.05).Conclusion During treatment of ulcerative colitis with spleen kidney Yand deficiency,combination therapy can achieve more definite curative effect than single therapy,can quickly reduce inflammatory response,improve clinical symptoms,and accelerate recovery process of patients.