卡前列素氨丁三醇应用于产后出血患者的效果及作用机制探讨

Effect and Action Mechanism Discussion of Carboprost Tromethamine for Patients with Postpartum Hemorrhage

目的 针对产后出血患者应用不同治疗方案的效果及各项指标的改善情况进行研究、分析。方法选取2020年—2021年8月本院收治的50例产后出血患者为研究对象,按随机数字表法将其分为A组、B组,每组25例。其中,A组应用缩宫素治疗,B组应用卡前列素氨丁三醇治疗,并持续观察至出血停止后7d。针对组间各项指标[疗效(治疗后)、产后出血情况(治疗后)、各项血清指标及凝血功能(治疗前、后)]进行的对比、分析。结果 治疗后,B组临床总有效率高于A组;产后24h血红蛋白下降值B组相较于A组低;第三产程时间B组相较于A组短;产后2h出血量B组相较于A组少;治疗后,两组的血浆Fg及血清NO、NOS、BNP水平均呈现出明显的降低趋势(相较于治疗之前),且B组处于更低水平(相较于A组而言);两组血浆APTT、PT均缩短(相较于治疗之前),且B组更短(相较于A组而言)上述差异有统计学意义(P<0.05)。结论 临床上在对产后出血患者治疗方案的选取中,相较于缩宫素,应用卡前列素氨丁三醇治疗的整体效果更佳,其在加强子宫收缩力、减少产后出血量等方面的效果更为显著。

Objective To carry on unified study and analysis on effect and improvement of various indicators of different treatment plans for postpartum hemorrhage patients.Methods The paper reviewed and studied 50 patients with postpartum hemorrhage(sample size:50 cases) in our hospital from June 2020 to August 2021,and divided them into group A and B,with 25 cases in each groups,(based on random number table method),treated with different treatment schemes(oxytocin for group A and carboprost tromethamine for group B),and observed condition for 7 days continuously after the cessation of bleeding.Various indicators were compared and analyzed between groups,including effect(after treatment),postpartum hemorrhage(after treatment),various serum indicators,and coagulation function(before and after treatment).Results After treatment,total clinical effective rate of group B was 92.00%,higher than 68.00% of group A.Decrease in hemoglobin levels at 24 hours postpartum in group B was lower than group A.The third stage of labor time in group B was shorter than group A.Group B had less bleeding at 2 hours postpartum than Group A.After treatment,plasma Fg and serum NO,NOS,and BNP levels of both groups showed significant decrease trend(compared than before treatment),and group B was at a lower level(than group A).Plasma APTT and PT of both groups were shortened(compared with before treatment),that of group B was shorter(than group A),Statistical processing result showed P< 0.05,with significant difference.Conclusion During clinical practice,carboprost tromethamine has better overall effect than oxytocin for postpartum hemorrhage patients,can strengthen uterine contractions and reduce postpartum hemorrhage,which has more significant effect.