中药外用穴位贴敷辅助治疗对晚期非小细胞肺癌患者生存质量的影响

Effect of External Application of Traditional Chinese Medicine Acupoint Application as Adjuvant Therapy on Life Quality of Patients with Advanced Non-Small Cell Lung Cancer

目的 观察中药外用穴位贴敷疗法对晚期非小细胞肺癌患者生存质量的影响。方法 选取2021年12月—2022年11月蚌埠医学院第一附属医院中医科诊治的经一线治疗后稳定的晚期非小细胞肺癌患者共139例,随机分为观察组(69例)和治疗组(70例)。观察组采用西医基础治疗,治疗组采用西医基础治疗+中药外用穴位贴敷。治疗前比较两组患者的一般指标(性别、年龄、病理类型、临床分期、一线疗效、合并基础疾病分布)、生存质量评分(生活质量调查问卷、Karnofsky功能状态量表)、中医证候评分及基础血检指标。治疗后比较两组患者生存质量评分、中医证候评分及基础血检指标。结果 治疗前,两组患者的各项指标结果无显著统计学差异(P>0.05);治疗后,治疗组的生存质量评分及中医证候评分均显著优于观察组(P<0.05)。两组患者治疗前后均无明显毒副反应,血检结果正常,提示所用中药外用穴位贴敷方式安全。结论 中药外用穴位贴敷疗法可以有效改善晚期非小细胞肺癌患者的临床症状,提高患者生活质量。

Objective To observe effect of external application of traditional Chinese medicine on life quality of patients with advanced non-small cell lung cancer.Methods The paper chose 139stable advanced non-small cell lung cancer patients in Department of Traditional Chinese Medicine of Bengbu Medical College the First Affiliated Hospital from December 2021 to November 2022,and divided them into observation group(69 cases) and treatment group(70 cases) randomly.Observation group was treated with basic treatment with western medicine,while treatment group with basic treatment with western medicine and external acupoint application with traditional Chinese medicine.Before treatment,general indicators(gender,age,pathological type,clinical stage,first-line Effect,distribution of underlying diseases),life quality scores(life quality survey questionnaire,Karnofsky functional status scale),traditional Chinese medicine syndrome scores,and basic blood test indicators were compared between two groups.Life quality scores,traditional Chinese medicine syndrome scores,and basic blood test indicators between two groups were compared after treatment.Results During experiment,3 cases were dropped out,and 136 effective cases were ultimately included(66in observation group and 70 in treatment group).There was no significant statistical difference in results of various indicators between two groups before treatment.After treatment,life quality scores and traditional Chinese medicine syndrome scores of treatment group were significantly better than observation group(P< 0.05).Both groups showed no significant toxic side effect before and after treatment,and blood test results were normal,indicating safe effect of external acupoint application method of traditional Chinese medicine.Conclusion External application of traditional Chinese medicine acupoint application therapy can improve clinical symptoms and life quality of advanced non-small cell lung cancer patients and effectively.