小剂量糖皮质激素联合茶碱对老年哮喘的治疗效果分析

Curative Effect Analysis of Low-Dose Glucocorticoids Combined with Theophylline on Elderly Asthma

目的 评价分析老年哮喘患者接受小剂量糖皮质激素的同时施加茶碱药物对临床效果的影响情况。方法 以本院收治的80例老年哮喘病患为研究主体,时间分布界限2022年1—12月,将40例病患归入参照组,执行常规布地奈德吸入剂治疗方案,把剩余40例病患纳入实验组,执行小剂量糖皮质激素与茶碱联合治疗方案,对两组的临床治疗效果、不良反应发生情况以及治疗前后嗜酸性粒细胞百分比指标水平、呼气峰值流速水平、第一秒用力呼气量检验结果、生活质量评分水平进行对比分析。结果 (1)相较于参照组,实验组治疗有效率达到更高,组间差异有统计学意义(P<0.05);(2)相较于参照组,实验组不良反应发生总水平达到更低,组间差异有统计学意义(P<0.05);(3)治疗后,两组各项检验结果均得到明显改善,且与参照组相比,实验组的嗜酸性粒细胞百分比检验结果明显降低,而其他两项检验结果升高显著,组间差异有统计学意义(P<0.05);(4)干预后,相较于参照组,实验组生活质量评分结果更优,组间差异有统计学意义(P<0.05)。结论 在老年哮喘病治疗过程中,运用小剂量糖皮质激素药物的同时,联合服用茶碱药物,能够达到理想的治疗效果,且能有效改善患者呼吸困难、咳痰、咳嗽等症状,治疗安全性比较高,可改善患者生活质量。

Objective To evaluate and analyze clinical effect of theophylline drugs and lowdose glucocorticoids for elderly asthma patients.Methods The paper chose 80 elderly asthma patients admitted to our hospital as study subjects,with time distribution boundary from January to December 2022.40 cases in reference group were treated with routine budesonide inhalation treatment,remaining 40 cases in experimental group with combination therapy of low-dose glucocorticoids and theophylline.Clinical treatment effect,incidence of adverse reactions,and eosinophil percentage,peak expiratory flow rate,first second forced expiratory volume test results,and life quality scores levels were compared and analyzed between two groups before and after treatment.Results(1) Experimental group had treatment effect rate of 97.50%(39/40),higher than reference group of 80.00%(32/40),with comparative difference(P<0.05).(2) Experimental group had higher overall level of adverse reactions of 5.00%(2/40) than reference group of 22.50%(9/40),with significant difference(P<0.05).(3) After treatment,results of various tests in both groups were significantly higher,percentage of eosinophils in experimental group was significantly lower than control group,results of the other two tests were significantly higher,with significant difference(P< 0.05).(4) After intervention,experimental group had better life quality scores than control group,difference was significant,(P< 0.05).Conclusion During treatment of elderly asthma,low-dose glucocorticoid drugs combined with theophylline drugs can achieve ideal curative effect and improve symptoms effectively including breathing difficulties,sputum,and cough,with relatively high treatment safety,which can improve living standards of patients.