血清甲胎蛋白检测在原发性肝癌诊断中的价值分析

Value Analysis of Serum Alpha Fetoprotein Detection in Diagnosis of Primary Liver Cancer

目的 分析血清甲胎蛋白检测在原发性肝癌诊断中的价值。方法 选取2021年1月—2022年12月来本院查治的57例原发性肝癌患者设为观察组,另选同期57例日常体检者设为对照组,所有受检者均接受血清甲胎蛋白检测,分析血清甲胎蛋白对原发性肝癌的检出率,通过ROC曲线确定血清甲胎蛋白对原发性肝癌的特异性、敏感性及最佳鉴别价值。结果 经血清甲胎蛋白检测共计检出47例原发性肝癌,血清甲胎蛋白对原发性肝癌患者的检测准确率为82.46%;观察组患者的血清甲胎蛋白水平与对照组比较具有显著性差异(P<0.05);血清甲胎蛋白值预测鉴别原发性肝癌ROC曲线下面积、特异度、敏感度分别为0.922、81.15%、94.07%,最佳判断值0.31。结论 血清甲胎蛋白检测在原发性肝癌的诊断和监测中具有许多优势,包括无创性、简便性、经济性、可重复性和广泛的应用范围。尽管存在一定的局限性,但血清甲胎蛋白仍然是一种重要的诊断工具,可以与其他诊断方式相结合,提高原发性肝癌的诊断准确性和治疗效果评估。

Objective To analyze value of serum alpha fetoprotein detection in diagnosis of primary liver cancer.Methods The paper chose 57 patients with primary liver cancer in our hospital from January 2021to December 2022 as observation group,and another 57 daily physical examination patients during the same period as control group.All subjects were treated with serum alpha fetoprotein testing,detection rate of serum alpha fetoprotein for primary liver cancer was analyzed.Specificity,sensitivity,and optimal differentiation threshold of serum alpha fetoprotein for primary liver cancer were determined by ROC curves.Results 47cases of primary liver cancer were detected through serum alpha fetoprotein testing,accuracy of serum alpha fetoprotein detection of patients with primary liver cancer was 82.46%,there was significant difference in serum alpha fetoprotein levels between observation group and control group(P<0.05).Area,specificity,and sensitivity under ROC curve for predicting serum alpha fetoprotein value in distinguishing primary liver cancer was 0.922,81.15%,and 94.07% respectively,with the best judgment value of 0.31.Conclusion Serum alpha fetoprotein can diagnose primary liver cancer patients accurately,with high specificity and sensitivity.